Recent advances in carboxymethyl chitosan-based materials for biomedical applications

Yongtao Geng; Hang Xue; Zhenhe Zhang; Adriana C Panayi; Samuel Knoedler; Wu Zhou; Bobin Mi; Guohui Liu

doi:10.1016/j.carbpol.2023.120555

Recent advances in carboxymethyl chitosan-based materials for biomedical applications

Carbohydr Polym. 2023 Apr 1:305:120555. doi: 10.1016/j.carbpol.2023.120555. Epub 2023 Jan 6.

Authors

Yongtao Geng¹, Hang Xue¹, Zhenhe Zhang¹, Adriana C Panayi², Samuel Knoedler³, Wu Zhou⁴, Bobin Mi⁵, Guohui Liu⁶

Affiliations

¹ Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
² Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwig-Guttmann-Strasse 13, 67071 Ludwigshafen/Rhine, Germany.
³ Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02152, USA; Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Max-Lebsche-Platz 31, 81377 Munich, Germany.
⁴ Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. Electronic address: 2016XH0120@hust.edu.cn.
⁵ Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. Electronic address: mibobin@hust.edu.cn.
⁶ Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. Electronic address: liuguohui@hust.edu.cn.

PMID: 36737218
DOI: 10.1016/j.carbpol.2023.120555

Abstract

Chitosan (CS) and its derivatives have been applied extensively in the biomedical field owing to advantageous characteristics including biodegradability, biocompatibility, antibacterial activity and adhesive properties. The low solubility of CS at physiological pH limits its use in systems requiring higher dissolving ability and a suitable drug release rate. Besides, CS can result in fast drug release because of its high swelling degree and rapid water absorption in aqueous media. As a water-soluble derivative of CS, carboxymethyl chitosan (CMC) has certain improved properties, rendering it a more suitable candidate for wound healing, drug delivery and tissue engineering applications. This review will focus on the antibacterial, anticancer and antitumor, antioxidant and antifungal bioactivities of CMC and the most recently described applications of CMC in wound healing, drug delivery, tissue engineering, bioimaging and cosmetics.

Keywords: Antibacterial properties; Carboxymethyl chitosan; Drug delivery; Tissue engineering; Wound healing.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antifungal Agents
Chemical Phenomena
Chitosan* / chemistry
Drug Delivery Systems / methods

Substances

Chitosan
Anti-Bacterial Agents
Antifungal Agents