Why does the pUG tail curl?

Mol Cell. 2023 Feb 2;83(3):330-331. doi: 10.1016/j.molcel.2022.12.010.

Abstract

Roschdi et al.1 report on a new, higher-order RNA structure folding from an alternating uridine (U)/guanosine (G) repeated sequence-the pUG tail-into a peculiar G-quadruplex structure-the pUG fold-found to orchestrate the gene-silencing activity of pUGylated RNAs.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dogs
  • G-Quadruplexes*
  • RNA*

Substances

  • RNA