When IL-17 gets on your nerves

Cell. 2023 Feb 2;186(3):466-468. doi: 10.1016/j.cell.2022.12.048.

Abstract

Microbiota-induced IL-17 production mediates CNS processes and animal behavior. However, its role on the peripheral nervous system (PNS) remains largely unknown. Enamorado et al. demonstrate that commensal-specific Th17 cells are recalled following tissue injury to support local nerve regeneration, a process orchestrated by IL-17 signaling on peripheral neurons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / physiology
  • Central Nervous System*
  • Interleukin-17*
  • Nerve Regeneration / physiology
  • Peripheral Nerves
  • Peripheral Nervous System
  • Signal Transduction

Substances

  • Interleukin-17