Dietary supplementation with casein/cyanidin-3-O-glucoside nanoparticles alters the gut microbiota in high-fat fed C57BL/6 mice

Qiyan Lyu; Hongting Deng; Shunxin Wang; Hesham El-Seedi; Hui Cao; Lei Chen; Hui Teng

doi:10.1016/j.foodchem.2023.135494

Dietary supplementation with casein/cyanidin-3-O-glucoside nanoparticles alters the gut microbiota in high-fat fed C57BL/6 mice

Food Chem. 2023 Jun 30:412:135494. doi: 10.1016/j.foodchem.2023.135494. Epub 2023 Jan 16.

Authors

Qiyan Lyu¹, Hongting Deng¹, Shunxin Wang¹, Hesham El-Seedi², Hui Cao¹, Lei Chen³, Hui Teng⁴

Affiliations

¹ Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
² Pharmacognosy Group, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, Uppsala 751 23, Sweden.
³ Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address: chenlei841114@hotmail.com.
⁴ Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address: tenghui850610@126.com.

PMID: 36736183
DOI: 10.1016/j.foodchem.2023.135494

Abstract

This study aims to investigate the dietary intervention effect of casein/cyanidin-3-O-glucoside nanoparticles (Cs-C3G) on high-fat-diet (HFD)induced gut microbiota disorders. In HFD-fed C57BL/6mice, Cs-C3G has ameliorated HFD-caused fat accumulation and liver oxidative stress. Cs-C3G as a dietary supplementation can restore the abundance and diversity of gut microbiota with descending the ratio of Firmicutes to Bacteroidetes, increasing some beneficial microorganisms, and reducing some opportunistic pathogenic bacteria. In general, Cs-C3G has a effect on regulating the disturbance of gut microbiota, and then prevents HFD-induced obesity and liver damage.

Keywords: Cyanidin-3-O-glucoside; Gut microbiota; High-fat-diet; Nanoparticles.

MeSH terms

Animals
Caseins* / pharmacology
Diet, High-Fat / adverse effects
Dietary Supplements
Gastrointestinal Microbiome*
Glucosides / pharmacology
Mice
Mice, Inbred C57BL

Substances

Caseins
cyanidin
Glucosides