Mapping cryptic binding sites of drug targets to overcome drug resistance

Yang-Yang Gao; Wei-Cheng Yang; Charles R Ashby Jr; Ge-Fei Hao

doi:10.1016/j.drup.2023.100934

Mapping cryptic binding sites of drug targets to overcome drug resistance

Drug Resist Updat. 2023 Mar:67:100934. doi: 10.1016/j.drup.2023.100934. Epub 2023 Jan 23.

Authors

Yang-Yang Gao¹, Wei-Cheng Yang¹, Charles R Ashby Jr², Ge-Fei Hao³

Affiliations

¹ National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China.
² Department of Pharmaceutical Sciences, St. John's University, New York, NY, USA. Electronic address: cnsratdoc@optonline.net.
³ National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China. Electronic address: gefei_hao@foxmail.com.

PMID: 36736042
DOI: 10.1016/j.drup.2023.100934

Abstract

The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their inhibitors can overcome drug resistance.

Keywords: Cryptic binding sites; Drug resistance; Resistance management.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Drug Resistance, Neoplasm*
Humans