[Moxibustion at Baihui combined with acupuncture for cervical vertigo: a Meta-analysis and trial sequential analysis]

Zhen Ci Yan Jiu. 2023 Jan 25;48(1):95-101. doi: 10.13702/j.1000-0607.20211054.
[Article in Chinese]

Abstract
in English, Chinese

Objective: To evaluate the efficacy and safety of moxibustion at Baihui (CV20) combined with acupuncture in treatment of cervical vertigo.

Methods: From the databases, such as CNKI, VIP, WanFang, CBM, PubMed, Cochrane Library and Embase, the studies of randomized controlled trials (RCTs) on moxibustion at CV20 combined with acupuncture for cervical vertigo were searched from inception to September 15th, 2021. The Cochrane risk of bias assessment tool was utilized to evaluate the quality of the included literature. Using RevMan5.3, Stata12.0 and TSA0.9.5.0 10 Beta software, the Meta-analysis and trial sequential analysis (TSA) were performed.

Results: Seventeen RCTs with 1 232 patients were included. Meta-analysis showed that in the trial group (moxibustion at CV20 combined with acupuncture), the total effective rate (RR=1.17, 95%CI［1.12, 1.22］, P<0.000 1), the curative and remarkably-effective rate (RR＝1.28，95%CI［1.20，1.36］，P<0.000 1) and the score of cervical vertigo (WMD=2.88, 95%CI［1.87, 3.89］, P<0.000 1) were all better when compared with the control group (simple acupuncture or electroacupuncture group). The results of trial sequential analysis indicated that for the cumulative Z-score of each RCT, the Z-curve crossed the conventional test boundary and TSA boundary, which further confirmed the clinical efficacy of moxibustion at CV20 combined with acupuncture on cervical vertigo.

Conclusion: The clinical efficacy of moxibustion at CV20 combined with acupuncture is determined in treatment of cervical vertigo.

目的：系统评价艾灸百会联合针刺治疗颈性眩晕(CV)的疗效及安全性。方法：计算机检索中国知网、维普、万方、中国生物医学文献数据库、PubMed、Cochrane Library、Embase数据库，检索日期为从建库至2021年9月15日，搜集以艾灸百会联合针刺治疗CV的随机对照试验，利用Cochrane 偏倚风险评估工具评价纳入文献的质量。采用RevMan5.3、Stata12.0、TSA0.9.5.10 Beta软件进行Meta分析和试验序贯分析(TSA)。结果：共纳入17篇文献，包括1 232例患者。Meta分析结果显示：试验组(艾灸百会联合针刺治疗)在临床总有效率［RR＝1.17，95% CI(1.12，1.22)，P<0.000 1］、愈显率 ［RR＝1.28，95%CI(1.20，1.36)，P<0.000 1］，改善眩晕症状与功能评分［WMD＝2.88，95% CI(1.87，3.89)，P<0.000 1］方面均优于对照组(单纯针刺或电针治疗)。TSA结果显示，临床总有效率累计纳入的研究穿过了传统界值和 TSA 界值，进一步肯定了艾灸百会联合针刺治疗CV的临床疗效。结论：艾灸百会联合针刺治疗CV的临床疗效明确。.

Keywords: Acupuncture; Baihui(CV20); Cervical vertigo; Meta-analysis; Moxibustion; Randomized controlled trial; Trial sequential analysis.

Publication types

  • Meta-Analysis
  • English Abstract

MeSH terms

  • Acupuncture Therapy* / methods
  • Electroacupuncture*
  • Humans
  • Moxibustion*
  • Treatment Outcome
  • Vertigo / therapy