For more than half a century，the modern bioresearch in acupuncture has made remarkable advancements, proving scientific basis underlying the traditional, intuitive treatment, as well as leading to some new discoveries with the potential to enhance the effectiveness of acupuncture as we know it. Meanwhile, the clinical researches have started to shift its paradigm from traditional individual observation to modern evidence-based medicine. However, there is little interaction between basic and clinic researches, which are like two separate worlds, not benefiting each other. Also the education and training of acupuncture are still traditional style, little combining with modern studies. To bridging the large gap, we need translational science involving in. In this article, with a critical reviews of the limitations of the traditional methods of acupuncture, the challenges faced by clinic practices and placebo-control studies, and the advantages and disadvantages of basic research, we propose a methodological paradigm of the translational research, Translational Acupuncture Research Spectrum, that meets the current situation of acupuncture researches, hoping to give insights into this field and to promote modern acupuncture to move towards a new stage.
半个多世纪的针灸现代研究已获得令人瞩目的成就。基础研究持续深入，不断取得突破性进展；临床研究已由个体化经验探索转向系统化循证试验, 成功的大数据研究越来越多。然而，诸多盲点与严重瓶颈的存在也是不争的事实。一个突出的问题是，教学、科研、临床间的严重脱节已成为阻碍许多问题正常解决甚至是产生某些问题的关键症结，而消除此类脱节问题亟需新型学科转化医学的研究理念与方法的介入。本文在综合分析针灸学传统方法的局限、循证试验所面临的挑战及基础研究的突破与未知等重要问题的基础上，尝试提出一个适合于针灸学科特点的转化医学研究的方法学模式——针灸转化医学研究谱，以冀推动针灸转化医学研究的系统性开展，为现代针灸学迈向一个新的发展阶段提供参考与启示。.
Keywords: Acupuncture; Translational acupuncture research spectrum; Translational medicine; Translational research.