Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina

Zhuolin Liu; Furu Zhang; Kelvy Zucca; Anant Agrawal; Daniel X Hammer

doi:10.1364/BOE.462594

Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina

Biomed Opt Express. 2022 Oct 17;13(11):5860-5878. doi: 10.1364/BOE.462594. eCollection 2022 Nov 1.

Authors

Zhuolin Liu¹, Furu Zhang^{1

2}, Kelvy Zucca¹, Anant Agrawal¹, Daniel X Hammer¹

Affiliations

¹ Center for Devices and Radiological Health (CDRH), U. S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993, USA.
² Co-first author.

Abstract

We describe the design and performance of a multimodal and multifunctional adaptive optics (AO) system that combines scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) for simultaneous retinal imaging at 13.4 Hz. The high-speed AO-OCT channel uses a 3.4 MHz Fourier-domain mode-locked (FDML) swept source. The system achieves exquisite resolution and sensitivity for pan-macular and transretinal visualization of retinal cells and structures while providing a functional assessment of the cone photoreceptors. The ultra-high speed also enables wide-field scans for clinical usability and angiography for vascular visualization. The FDA FDML-AO system is a powerful platform for studying various retinal and neurological diseases for vision science research, retina physiology investigation, and biomarker development.