[A Case of Meningeal Carcinomatosis of Gastric Cancer Successfully Controlled with Nab-Paclitaxel]

Gan To Kagaku Ryoho. 2022 Dec;49(13):1702-1704.
[Article in Japanese]

Abstract

We report a 76-year-old woman with meningeal carcinomatosis after gastric cancer surgery. During adjuvant chemotherapy, metastasis to the left axillary and Virchow's lymph node was suspected. A resection biopsy revealed gastric cancer metastasis, and PTX plus RAM therapy was started. Due to RAM adverse events, the treatment was changed to weekly nab- PTX, which was continued for about 6 months. During the 8th course, she was hospitalized due to worsening headache and lightheadedness. Meningeal carcinomatosis was diagnosed by cytology of CSF examination and MRI findings. She died on the 16th day after admission. Meningeal carcinomatosis has a rapidly progressive course with poor prognosis. This case shows nab-PTX may have been able to control the progression.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Albumins / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Female
  • Humans
  • Lymphatic Metastasis
  • Meningeal Carcinomatosis* / diagnosis
  • Meningeal Carcinomatosis* / drug therapy
  • Paclitaxel / therapeutic use
  • Stomach Neoplasms* / drug therapy
  • Stomach Neoplasms* / pathology
  • Stomach Neoplasms* / surgery

Substances

  • 130-nm albumin-bound paclitaxel
  • Paclitaxel
  • Albumins