Two-phase flow separation is a key step in various downstream purification processes. The use of a separator with controllable flow behavior is recommended to avoid contamination. In this study, a core-annular separator for biphasic flow separation with four different chemical polarities was developed, and two machine learning-based methods were proposed for answering two emergent questions to meet real industrial needs. (1) Could complete two-phase separation be achieved under these operating conditions? (2) Could the separation process be accelerated by determining the maximum input flow rate of the water? Process prediction for automation, machine learning-based classifiers, and multilayer perceptron were used to address these questions by predicting successful separation and the maximum input flow rates of unknown water-solvent systems with limited experimental data as training samples. The core-annular separator achieved complete two-phase water-solvent separation at a maximum total input flow rate of 4000 μL min-1. Moreover, the classification accuracy for complete separation reached 92.2%, and the multilayer perceptron network had the best performance for predicting the flow rate. This liquid-liquid interface manipulation separator and machine learning method could decrease the cost of relevant process development.
Keywords: classifiers; machine learning; majority-voting algorithm; multilayer perceptron; phase separation.