Edge-Enhancing Gradient-Echo MP2RAGE for Clinical Epilepsy Imaging at 7T

S Tao; X Zhou; E Greco; V Gupta; B E Freund; E M Westerhold; A M Feyissa; W O Tatum; S Grewal; V Patel; E H Middlebrooks

doi:10.3174/ajnr.A7782

Edge-Enhancing Gradient-Echo MP2RAGE for Clinical Epilepsy Imaging at 7T

AJNR Am J Neuroradiol. 2023 Mar;44(3):268-270. doi: 10.3174/ajnr.A7782. Epub 2023 Feb 2.

Authors

S Tao¹, X Zhou², E Greco², V Gupta², B E Freund³, E M Westerhold², A M Feyissa³, W O Tatum³, S Grewal⁴, V Patel², E H Middlebrooks^{2

4}

Affiliations

¹ From the Departments of Radiology (S.T., X.Z., E.G., V.G., E.M.W., V.P., E.H.M.) Tao.Shengzhen@mayo.edu.
² From the Departments of Radiology (S.T., X.Z., E.G., V.G., E.M.W., V.P., E.H.M.).
³ Neurology (B.E.F., A.M.F., W.O.T.).
⁴ Neurosurgery (S.G., E.H.M.), Mayo Clinic, Jacksonville, Florida.

Abstract

The 3D edge-enhancing gradient-echo (EDGE) MR imaging sequence offers superior contrast-to-noise ratio in the detection of focal cortical dysplasia. EDGE could benefit from 7T MR imaging but also faces challenges such as image inhomogeneity and low acquisition efficiency. We propose an EDGE-MP2RAGE sequence that can provide both EDGE and T1-weighted contrast, simultaneously, improving data-acquisition efficiency. We demonstrate that with sequence optimization, EDGE images with sufficient uniformity and T1-weighted images with high gray-to-white matter contrast can be achieved.

MeSH terms

Brain / diagnostic imaging
Cerebral Cortex
Epilepsy* / diagnostic imaging
Gray Matter
Humans
Magnetic Resonance Imaging / methods
White Matter*