Role of genetic factors in different swine breeds exhibiting varying levels of resistance/susceptibility to PRRSV

Xiangbin You; Gan Li; Ying Lei; Zhiqian Xu; Ping Zhang; Youbing Yang

doi:10.1016/j.virusres.2023.199057

Role of genetic factors in different swine breeds exhibiting varying levels of resistance/susceptibility to PRRSV

Virus Res. 2023 Mar:326:199057. doi: 10.1016/j.virusres.2023.199057. Epub 2023 Feb 3.

Authors

Xiangbin You¹, Gan Li¹, Ying Lei¹, Zhiqian Xu¹, Ping Zhang¹, Youbing Yang²

Affiliations

¹ College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang 471023, China.
² College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang 471023, China. Electronic address: 9906133@haust.edu.cn.

Abstract

Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is an economically significant contagious disease. Traditional approaches based on vaccines or medicines were challenging to control PRRSV due to the diversity of viruses. Different breeds of pigs infected with PRRSV have been reported to have different immune responses. However, due to the complexity of interaction mechanism between host and PRRSV, the genetic mechanism leading to PRRSV susceptibility/resistance in various pig breeds is still unclear. Herein, the role of host genetic components in PRRSV susceptibility is systematically described, and the molecular mechanisms by which host genetic factors such as SNPs, cytokines, receptor molecules, intestinal flora, and non-coding RNAs regulate PRRSV susceptibility/resistance. Therefore, improving the resistance to disease of individual animals through disease-resistance breeding technology is of profound significance for uplifting the sustainable and healthy development of the pig industry.

Keywords: Gut microbiota; Non-coding RNAs; PRRSV; Pig; Receptor; Resistance/susceptibility; SNPs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytokines / genetics
Porcine Reproductive and Respiratory Syndrome* / genetics
Porcine respiratory and reproductive syndrome virus* / genetics
Swine

Substances

Cytokines