Photofunctionalized TiO2-TiN micropattern coating with anticoagulant properties and ECs contact-guidance effect

Xiao Chen; Linhua Li; Xiaoqi Liu; Yuzhen Liao; Chao Qu; Hong Sun; Ansha Zhao; Ping Yang; Nan Huang; Jiang Chen

doi:10.1016/j.colsurfb.2023.113150

Photofunctionalized TiO₂-TiN micropattern coating with anticoagulant properties and ECs contact-guidance effect

Colloids Surf B Biointerfaces. 2023 Mar:223:113150. doi: 10.1016/j.colsurfb.2023.113150. Epub 2023 Jan 20.

Authors

Xiao Chen¹, Linhua Li², Xiaoqi Liu³, Yuzhen Liao⁴, Chao Qu², Hong Sun⁴, Ansha Zhao⁴, Ping Yang⁴, Nan Huang⁴, Jiang Chen⁵

Affiliations

¹ The Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Institute of Biomaterials and Surface Engineering, Key Laboratory for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China.
² The Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
³ Sichuan Provincial Key Laboratory for Human Disease Gene Study, the Department of Medical Genetics, the Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, Chengdu, China.
⁴ Institute of Biomaterials and Surface Engineering, Key Laboratory for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China.
⁵ The Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: 283876533@qq.com.

PMID: 36731267
DOI: 10.1016/j.colsurfb.2023.113150

Abstract

Titanium nitride (TiN) and titanium dioxide (TiO₂) are two titanium-based coatings commonly used in cardiovascular stent surface engineering. Generally, TiN has good mechanical properties and endothelial cell (ECs) compatibility but poor anticoagulant properties and cannot modulate cell growth orientation and morphology. TiO₂ has excellent corrosion resistance and biosafety. Besides, TiO₂ has the photocatalytic anticoagulant property, which can migrate to other materials tens of microns away. Based on the above properties, a striped TiO₂-TiN micropattern coating was designed and fabricated in this study, and the coating was photofunctionalized by UV irradiation. The obtained photo-functionalized TiO₂-TiN micropattern coating showed anticoagulant properties by the migrating effect of the photocatalytic anticoagulant property of TiO₂. Besides, the TiO₂-TiN micropattern coatings showed ECs compatibility. Furthermore, the growth orientation and cell shape of ECs on TiO₂-TiN samples were effectively regulated by the stripe pattern's contact guidance effect, which was particularly evident on the photo-functionalized TiO₂-TiN samples. We envision that this photofunctionalized TiO₂-TiN striped micropattern coating has significant potential for the surface engineering of vascular stents.

Keywords: Anticoagulant ability; Endothelial cell orientation; Photocatalysis; TiO(2)-TiN micropattern; Titanium nitride (TiN).

MeSH terms

Anticoagulants*
Titanium* / radiation effects

Substances

Anticoagulants
Titanium
titanium dioxide
titanium nitride