Fabrication of graphene oxide/copper synergistic antibacterial coating for medical titanium substrate

Fengjuan Yang; Dongliang Huo; Jinglin Zhang; Tongyao Lin; Jingxian Zhang; Shaozao Tan; Lili Yang

doi:10.1016/j.jcis.2023.01.114

Fabrication of graphene oxide/copper synergistic antibacterial coating for medical titanium substrate

J Colloid Interface Sci. 2023 May 15:638:1-13. doi: 10.1016/j.jcis.2023.01.114. Epub 2023 Jan 26.

Authors

Fengjuan Yang¹, Dongliang Huo¹, Jinglin Zhang², Tongyao Lin¹, Jingxian Zhang¹, Shaozao Tan³, Lili Yang⁴

Affiliations

¹ Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, PR China.
² Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, PR China; School of Light Industry and Materials, Guangdong Polytechnic, Foshan 528041, PR China.
³ Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, PR China. Electronic address: tsztan@jnu.edu.cn.
⁴ Analytical and Testing Center, Jinan University, Guangzhou 510632, PR China. Electronic address: Yanglili@jnu.edu.cn.

PMID: 36731214
DOI: 10.1016/j.jcis.2023.01.114

Abstract

Titanium (Ti) was an excellent medical metal material, but the lack of good antibacterial activity confined its further practical application. To solve this dilemma, a coating containing graphene oxide (GO) and copper (Cu) was prepared on the surface of Ti sheet (Ti/APS/GO/Cu). First, physical sterilization could be carried out through the sharp-edged sheet structure of GO. Second, the oxygen-containing functional group on the surface of GO and the released Cu²⁺ would generate reactive oxygen species for chemical sterilization. The synergistic effect of GO and Cu substantially enhanced the in vitro and in vivo antibacterial property of Ti sheet, thereby reducing bacterial-related inflammation. Quantitatively, the antibacterial rate of Ti/APS/GO/Cu against E. coli or S. aureus reached over 99%. Besides, Ti/APS/GO/Cu showed excellent biocompatibility and no toxicity to cell. Such work developed multiple sterilization avenues to design non-antibiotic, safe and efficient antibacterial implant material for the biomedical domain.

Keywords: Coating; Copper; Graphene oxide; Synergistic antibacterial; Titanium.

MeSH terms

Anti-Bacterial Agents / chemistry
Copper* / chemistry
Escherichia coli
Staphylococcus aureus*
Titanium / chemistry

Substances

Copper
graphene oxide
titanium dioxide
Titanium
Anti-Bacterial Agents