Predominance of High-Level Tetracycline-Resistant Neisseria gonorrhoeae in Kenya: Implications for Global Implementation of Doxycycline Postexposure Prophylaxis for Prevention of Sexually Transmitted Infections

Sex Transm Dis. 2023 May 1;50(5):317-319. doi: 10.1097/OLQ.0000000000001769. Epub 2023 Jan 13.

Abstract

Using archived Neisseria gonorrhoeae samples from 2008 to 2012, the prevalence of tet (M) genemediating high-level tetracycline resistance in N. gonorrhoeae was 96% among 50 Kenyan women. Determining the local and national prevalence of gonococcal tetracycline resistance and surveillance of gonococcal antimicrobial resistance can inform the implementation of doxycycline postexposure prophylaxis for STI prevention.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Doxycycline / pharmacology
  • Doxycycline / therapeutic use
  • Drug Resistance, Bacterial
  • Female
  • Gonorrhea* / drug therapy
  • Gonorrhea* / epidemiology
  • Gonorrhea* / prevention & control
  • Humans
  • Kenya / epidemiology
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae
  • Sexually Transmitted Diseases* / drug therapy

Substances

  • Doxycycline
  • Anti-Bacterial Agents