Construction and prognostic value of enhanced CT image omics model for noninvasive prediction of HRG in bladder cancer based on logistic regression and support vector machine algorithm

Qing Li; Yang Luo; Dawei Liu; Bin Li; Yufeng Liu; Tao Wang

doi:10.3389/fonc.2022.966506

Construction and prognostic value of enhanced CT image omics model for noninvasive prediction of HRG in bladder cancer based on logistic regression and support vector machine algorithm

Front Oncol. 2023 Jan 16:12:966506. doi: 10.3389/fonc.2022.966506. eCollection 2022.

Authors

Qing Li¹, Yang Luo¹, Dawei Liu¹, Bin Li¹, Yufeng Liu¹, Tao Wang¹

Affiliation

¹ Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Abstract

Background: Urothelial Carcinoma of the bladder (BLCA) is the most prevalent cancer of the urinary system. In cancer patients, HRG fusion is linked to a poor prognosis. The prediction of HRG expression by imaging omics in BLCA has not yet been fully investigated.

Methods: HRG expression in BLCA and healthy adjoining tissues was primarily identified utilizing data sourced from The Cancer Genome Atlas (TCGA). Using Kaplan-Meier survival curves and Landmark analysis, the relationship between HRG expression, clinicopathological parameters, and overall survival (OS) was investigated. Additionally, gene set variation analysis (GSVA) was conducted and CIBERSORTx was used to investigate the relationship between HRG expression and immune cell infiltration. The Cancer Imaging Archive (TCIA) provided CT images that were used for prognostic analysis, radiomic feature extraction, and construction of the model, respectively. The HRG expression levels were predicted using the constructed and evaluated LR and SMV models.

Results: HRG expression was shown to be substantially lower in BLCA tumors as opposed to that observed in normal tissues (p < 0.05). HRG expression had a close positive relationship with Eosinophils and a close negative relationship with B cells naive. The findings of the Landmark analysis illustrated that higher HRG was associated with improved patient survival at an early stage (P=0.048). The predictive performance of the two models, based on logistic regression analysis and support vector machine, was outstanding in the training and validation sets, yielding AUCs of 0.722 and 0.708, respectively, in the SVM model, and 0.727 and 0.662, respectively, in the LR.The models have good predictive efficiency.

Conclusion: HRG expression levels can have a significant impact on BLCA patients' prognoses. The radiomic characteristics can successfully predict the pre-surgical HRG expression levels, based on CT- Image omics.

Keywords: HRG; bladder urothelial carcinoma; logistic regression; prognosis; support vector machine.