Associations of Long-Term Physical Activity Trajectories With All-Cause Mortality in a General Population

Chia-Lin Lee; Wei-Ju Liu; Ching-Hsien Chen; Jun-Sing Wang

doi:10.3389/ijph.2023.1605332

Associations of Long-Term Physical Activity Trajectories With All-Cause Mortality in a General Population

Int J Public Health. 2023 Jan 16:68:1605332. doi: 10.3389/ijph.2023.1605332. eCollection 2023.

Authors

Chia-Lin Lee^{1

2

3

4}, Wei-Ju Liu⁴, Ching-Hsien Chen⁵, Jun-Sing Wang^{1

2

3

6}

Affiliations

¹ Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
² Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
³ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
⁴ Intelligent Data Mining Laboratory, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
⁵ Divisions of Nephrology and Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA, United States.
⁶ Rong Hsing Research Center for Translational Medicine, Institute of Biomedical Science, National Chung Hsing University, Taichung, Taiwan.

Abstract

Objectives: We investigated the associations of mean levels of leisure-time physical activity (LTPA) and latent LTPA trajectories with all-cause mortality risk. Methods: Trajectories of LTPA were established using group-based trajectory analysis with a latent class growth model in a population-based cohort between 1996 and 2014. A Cox-proportional hazard model was conducted to examine the associations of LTPA quintiles and LTPA trajectories with all-cause mortality. Results: A total of 21,211 participants (age 18-90 years) were analyzed (median follow-up 16.8 years). The study participants were divided into five groups according to percentiles of LTPA (<20th, 20th-<40th, 40th-<60th, 60th-<80th, ≥80th) and LTPA trajectories (low/stable, medium/stable, increasing, decreasing, and fluctuating), respectively. Participants with a decreasing trajectory did not have a significantly lower risk of all-cause mortality despite having the highest baseline level of LTPA. In contrast, participants with a medium/stable (HR 0.84, 95% CI 0.72-0.98, p = 0.031) or an increasing (HR 0.57, 95% CI 0.33-0.97, p = 0.037) trajectory had a significantly lower risk of all-cause mortality. Conclusion: Promotion of maintaining stable LTPA is beneficial for public health and survival.

Keywords: metabolic equivalent; mortality; physical activity; population; trajectory.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Exercise*
Humans
Leisure Activities*
Middle Aged
Motor Activity
Proportional Hazards Models
Risk Factors
Young Adult

Grants and funding

The authors declare that this study received funding from Taichung Veterans General Hospital, Taichung, Taiwan (TCVGH-1093504C, TCVGH-1097316C, TCVGH-1097327D, TCVGH-1103502C, and TCVGH-1113502C). The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.