Ultra-high performance liquid chromatography coupled to ion mobility quadrupole time-of-flight mass spectrometry for the identification of non-volatile compounds migrating from 'natural' dishes

Magdalena Wrona; Ana Román; Xue-Chao Song; Cristina Nerín; Nicola Dreolin; Jeff Goshawk; Esther Asensio

doi:10.1016/j.chroma.2023.463836

Ultra-high performance liquid chromatography coupled to ion mobility quadrupole time-of-flight mass spectrometry for the identification of non-volatile compounds migrating from 'natural' dishes

J Chromatogr A. 2023 Feb 22:1691:463836. doi: 10.1016/j.chroma.2023.463836. Epub 2023 Jan 28.

Authors

Magdalena Wrona¹, Ana Román², Xue-Chao Song³, Cristina Nerín⁴, Nicola Dreolin⁵, Jeff Goshawk⁶, Esther Asensio⁷

Affiliations

¹ Department of Analytical Chemistry, Aragon Institute of Engineering Research I3A, EINA-University of Zaragoza, Torres Quevedo Building, María de Luna St. 3, E-50018 Zaragoza, Spain. Electronic address: magdalena.wrona@unizar.es.
² Department of Analytical Chemistry, Aragon Institute of Engineering Research I3A, EINA-University of Zaragoza, Torres Quevedo Building, María de Luna St. 3, E-50018 Zaragoza, Spain. Electronic address: 761807@unizar.es.
³ Department of Analytical Chemistry, Aragon Institute of Engineering Research I3A, EINA-University of Zaragoza, Torres Quevedo Building, María de Luna St. 3, E-50018 Zaragoza, Spain. Electronic address: 790929@unizar.es.
⁴ Department of Analytical Chemistry, Aragon Institute of Engineering Research I3A, EINA-University of Zaragoza, Torres Quevedo Building, María de Luna St. 3, E-50018 Zaragoza, Spain. Electronic address: cnerin@unizar.es.
⁵ Waters Corporation, Wilmslow, SK9 4AX, United Kingdom. Electronic address: nicola_dreolin@waters.com.
⁶ Waters Corporation, Wilmslow, SK9 4AX, United Kingdom. Electronic address: jeff_goshawk@waters.com.
⁷ Department of Analytical Chemistry, Aragon Institute of Engineering Research I3A, EINA-University of Zaragoza, Torres Quevedo Building, María de Luna St. 3, E-50018 Zaragoza, Spain. Electronic address: estherac@unizar.es.

PMID: 36724720
DOI: 10.1016/j.chroma.2023.463836

Abstract

Although most new biomaterials for food industry applications are labelled '100% natural fabrication' and 'chemical-free', certain compounds may migrate from those materials to the food, compromising the organoleptic characteristics and safety of the product. In this work, the degree of compound migration from dishes made with four different biomaterials: bamboo, palm leaf, wood and wheat pulp was investigated. Migration tests were carried out using three food simulants, 10% ethanol (simulant A), 3% acetic acid (simulant B), and 95% ethanol (simulant D2). Unequivocal identification of non-intentionally added substances (NIAS) is challenging even when using high-resolution mass spectrometry techniques however, a total of 25 different non-volatile compounds from the migration tests were identified and quantified using Ultra-high performance liquid chromatography coupled to ion mobility quadrupole time-of-flight mass spectrometry (UPLC-IMS-MS). In the bamboo samples three oligomers, cyclic diethylene glycol adipate, 3,6,9,16,19,22-hexaoxabicyclo[22.3.1]-octacosa-1(28),24,26-triene-2,10,15,23-tetrone and 1,4,7,14,17,20-hexaoxacyclohexacosane-8,13,21,26-tetrone exceeded the specified limits of migration.

Keywords: CCS values; Food contact biomaterials; Food safety; Migration; UPLC-IMS-MS.

MeSH terms

Chromatography, High Pressure Liquid
Food Contamination* / analysis
Food Packaging*
Ion Mobility Spectrometry
Mass Spectrometry / methods