68Ga-FAPI PET/CT Imaging of Intracranial Syphilitic Gumma: Comparison to 18F-FDG PET/CT

Clin Nucl Med. 2023 Mar 1;48(3):273-275. doi: 10.1097/RLU.0000000000004479. Epub 2022 Dec 24.

Abstract

Intracranial syphilitic gumma is a rare neurological disease. We present 68Ga-DOTA-FAPI-04 and 18F-FDG PET/CT findings of intracranial syphilitic gumma in a 46-year-old man with HIV. In this case, 68Ga-DOTA-FAPI-04 PET/CT outperforms 18F-FDG in helping to visualizing syphilitic gumma. Syphilitic gumma can also cause increase FAPI activity. Our findings suggest the potential value of 68Ga-DOTA-FAPI-04 in the diagnosis of syphilis.

Publication types

  • Case Reports

MeSH terms

  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Middle Aged
  • Positron Emission Tomography Computed Tomography*
  • Rare Diseases
  • Syphilis*

Substances

  • 68Ga-FAPI
  • Fluorodeoxyglucose F18

Supplementary concepts

  • Syphilis, tertiary