Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report

Jennifer Cable; Siddharth Balachandran; Lisa P Daley-Bauer; Arjun Rustagi; Ferrin Antony; Justin J Frere; Jamie Strampe; Katherine Kedzierska; Judy L Cannon; Maureen A McGargill; Daniela Weiskopf; Robert C Mettelman; Julia Niessl; Paul G Thomas; Bryan Briney; Sophie A Valkenburg; Jesse D Bloom; Pamela J Bjorkman; Sho Iketani; C Garrett Rappazzo; Chelsea M Crooks; Kali F Crofts; Stefan Pöhlmann; Florian Krammer; Andrea J Sant; Gary J Nabel; Stacey Schultz-Cherry

doi:10.1111/nyas.14960

Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report

Ann N Y Acad Sci. 2023 Mar;1521(1):32-45. doi: 10.1111/nyas.14960. Epub 2023 Jan 30.

Authors

Jennifer Cable¹, Siddharth Balachandran², Lisa P Daley-Bauer³, Arjun Rustagi⁴, Ferrin Antony⁵, Justin J Frere⁶, Jamie Strampe⁷, Katherine Kedzierska⁸, Judy L Cannon⁹, Maureen A McGargill¹⁰, Daniela Weiskopf¹¹, Robert C Mettelman¹⁰, Julia Niessl¹², Paul G Thomas^{10

13}, Bryan Briney¹⁴, Sophie A Valkenburg¹⁵, Jesse D Bloom^{16

17}, Pamela J Bjorkman¹⁸, Sho Iketani¹⁹, C Garrett Rappazzo²⁰, Chelsea M Crooks²¹, Kali F Crofts²², Stefan Pöhlmann²³, Florian Krammer²⁴, Andrea J Sant²⁵, Gary J Nabel²⁶, Stacey Schultz-Cherry²⁷

Affiliations

¹ PhD Science Writer, New York, New York, USA.
² Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
³ Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.
⁴ Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, California, USA.
⁵ Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
⁶ East Harlem Health Outreach Partnership; Department of Medical Education; and Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁷ Bioinformatics Program, Boston University and National Emerging Infectious Diseases Laboratories, Boston, Massachusetts, USA.
⁸ Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
⁹ Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
¹⁰ Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
¹¹ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, California, USA.
¹² Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.
¹³ Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
¹⁴ Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA.
¹⁵ HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China.
¹⁶ Basic Sciences Division and Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
¹⁷ Department of Microbiology and Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
¹⁸ Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
¹⁹ Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
²⁰ Adimab LLC, Lebanon, New Hampshire, USA.
²¹ Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
²² Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
²³ Infection Biology Unit, German Primate Center and Faculty of Biology and Psychology, University Medical Center Göttingen, Georg-August-University Göttingen, Göttingen, Germany.
²⁴ Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
²⁵ Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
²⁶ Modex Therapeutics Inc., an OPKO Health Company, Natick, Massachusetts, USA.
²⁷ Department of Laboratory Medicine and Department of Immunology, Yale University School of Medicine, New Haven, Connecticut, USA.

PMID: 36718537
DOI: 10.1111/nyas.14960

Abstract

Viruses infect millions of people each year. Both endemic viruses circulating throughout the population as well as novel epidemic and pandemic viruses pose ongoing threats to global public health. Developing more effective tools to address viruses requires not only in-depth knowledge of the virus itself but also of our immune system's response to infection. On June 29 to July 2, 2022, researchers met for the Keystone symposium "Viral Immunity: Basic Mechanisms and Therapeutic Applications." This report presents concise summaries from several of the symposium presenters.

Keywords: B cells; SARS-CoV-2; T cells; antibodies; influenza; vaccines; viral infection.

Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report

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