Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Maomao Xie; Meng Gao; Yang Yun; Martin Malmsten; Vincent M Rotello; Radek Zboril; Omid Akhavan; Aliaksandr Kraskouski; John Amalraj; Xiaoming Cai; Jianmei Lu; Huizhen Zheng; Ruibin Li

doi:10.1002/anie.202217345

Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Angew Chem Int Ed Engl. 2023 Apr 17;62(17):e202217345. doi: 10.1002/anie.202217345. Epub 2023 Feb 14.

Authors

Maomao Xie¹, Meng Gao¹, Yang Yun², Martin Malmsten^{3

4}, Vincent M Rotello⁵, Radek Zboril^{6

7}, Omid Akhavan⁸, Aliaksandr Kraskouski⁹, John Amalraj¹⁰, Xiaoming Cai¹¹, Jianmei Lu¹², Huizhen Zheng¹, Ruibin Li¹

Affiliations

¹ State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, 215123, Jiangsu, China.
² College of Environmental & Resource Sciences, Shanxi University, Taiyuan, 030006, Shanxi, China.
³ Department of Pharmacy, University of Copenhagen, 2100, Copenhagen, Denmark.
⁴ Department of Physical Chemistry 1, University of Lund, 22100, Lund, Sweden.
⁵ Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, USA.
⁶ Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute (CATRIN), Palacký University Olomouc, Šlechtitelů 241/27, Olomouc, 783 71, Czech Republic.
⁷ Nanotechnology Centre, Centre of Energy and Environmental Technologies, VŠB-Technical University of Ostrava, 17. listopadu 2172/15, Ostrava-Poruba, 708 00, Czech Republic.
⁸ Condensed Matter National Laboratory, P.O. Box 1956838861, Tehran, Iran.
⁹ Department of Physicochemistry of Thin Film Materials, Institute of Chemistry of New Materials of NAS of Belarus, 36 F. Skaryna Str., 220084, Minsk, Belarus.
¹⁰ Laboratory of Materials Science, Instituto de Química de Recursos Naturales, Universidad de Talca, P.O. Box 747, Talca, Chile.
¹¹ School of Public Health, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China.
¹² College of Chemistry, Chemical Engineering and Materials Science, National Center for International Research on Intelligent Nano-Materials and Detection Technology in Environmental Protection, Soochow University, Suzhou, 215123, China.

PMID: 36718001
DOI: 10.1002/anie.202217345

Abstract

Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.

Keywords: Antibacterial Nanomaterials; Antimicrobial Resistance; Killing Mechanism; Nano-Bio Interaction; Structure-Activity Relationship.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Anti-Bacterial Agents* / pharmacology
Drug Resistance, Bacterial
Nanostructures*

Substances

Anti-Bacterial Agents

Grants and funding

AI134770/National Institutes of Health (NIH)