Aquaporins in Tumor

Abudumijiti Abulizi; Awaguli Dawuti; Baoxue Yang

doi:10.1007/978-981-19-7415-1_21

Aquaporins in Tumor

Adv Exp Med Biol. 2023:1398:303-315. doi: 10.1007/978-981-19-7415-1_21.

Authors

Abudumijiti Abulizi¹, Awaguli Dawuti², Baoxue Yang³

Affiliations

¹ Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, China. Abulizi@shzu.edu.cn.
² Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
³ School of Basic Medical Sciences, Peking University, Beijing, China.

PMID: 36717503
DOI: 10.1007/978-981-19-7415-1_21

Abstract

Recent researches have demonstrated that aquaporins (AQPs), including water-selective channels, aquaglyceroporins and superaquaporins, are generally expressed in various tumors, such as lung, colorectal, liver, brain, breast tumors, etc. Therefore, it is imperative to study the accurate relationship between AQPs and tumor, which may provide innovative approaches to treat and prevent tumor development. In this chapter, we mainly reviewed the expression and pathophysiological function of AQPs in tumor, and summarize recent work on AQPs in tumor. Although, the underlying mechanism of AQP in tumor is not very clear, growing evidences suggest that cell migration, adhesion, angiogenesis, and division contribute to tumor development, in which AQPs might be involved. Therefore, it is still necessary to conduct further studies to determine the specific roles of AQPs in the tumor.

Keywords: Aquaporins; Pathophysiology; Tumor.

MeSH terms

Aquaporins* / genetics
Aquaporins* / metabolism
Cell Movement / genetics
Humans
Neoplasms* / genetics
Neoplasms* / metabolism

Substances

Aquaporins