Aquaporins in Immune System

Yazhu Quan; Bo Kan; Baoxue Yang

doi:10.1007/978-981-19-7415-1_13

Aquaporins in Immune System

Adv Exp Med Biol. 2023:1398:195-202. doi: 10.1007/978-981-19-7415-1_13.

Authors

Yazhu Quan^{1

2

3}, Bo Kan⁴, Baoxue Yang⁵

Affiliations

¹ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
² Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, China.
³ Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.
⁴ Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, China.
⁵ School of Basic Medical Sciences, Peking University, Beijing, China. baoxue@bjmu.edu.cn.

PMID: 36717495
DOI: 10.1007/978-981-19-7415-1_13

Abstract

Recent studies have shown that at least six aquaporins (AQPs), including AQP1, AQP3, AQP4, AQP5, AQP7, and AQP9, are expressed in immune system. These AQPs distribute in lymphocytes, macrophages, dendritic cells, and neutrophils, and mediate water and glycerol transportation in these cells, which play important roles in innate and adaptive immune functions. Immune system plays important roles in body physiological functions and health. Therefore, understanding the association between AQPs and immune system may provide approaches to prevent and treat related diseases. Here we will discuss the expression and physiological functions of AQPs in immune system and summarize recent researches on AQPs in immune diseases.

Keywords: Dendritic cells; Immune cells; Macrophage; Neutrophils; Water.

MeSH terms

Aquaporins* / genetics
Aquaporins* / metabolism
Immune System / metabolism
Water / metabolism

Substances

Aquaporins
Water