Aquaporins in Urinary System

Zhiwei Qiu; Tao Jiang; Yingjie Li; Weiling Wang; Baoxue Yang

doi:10.1007/978-981-19-7415-1_11

Aquaporins in Urinary System

Adv Exp Med Biol. 2023:1398:155-177. doi: 10.1007/978-981-19-7415-1_11.

Authors

Zhiwei Qiu¹, Tao Jiang², Yingjie Li¹, Weiling Wang³, Baoxue Yang⁴

Affiliations

¹ State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.
² College of Basic Medicine, Beihua University, Jilin, China.
³ Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, P.R. China.
⁴ School of Basic Medical Sciences, Peking University, Beijing, China. baoxue@bjmu.edu.cn.

PMID: 36717493
DOI: 10.1007/978-981-19-7415-1_11

Abstract

There are at least eight aquaporins (AQPs) expressed in the kidney. Including AQP1 expressed in proximal tubules, thin descending limb of Henle and vasa recta; AQP2, AQP3, AQP4, AQP5, and AQP6 expressed in collecting ducts; AQP7 expressed in proximal tubules; AQP8 expressed in proximal tubules and collecting ducts; and AQP11 expressed in the endoplasmic reticulum of proximal tubular epithelial cells. Over years, researchers have constructed different AQP knockout mice and explored the effect of AQP knockout on kidney function. Thus, the roles of AQPs in renal physiology are revealed, providing very useful information for addressing fundamental questions about transepithelial water transport and the mechanism of near isoosmolar fluid reabsorption. This chapter introduces the localization and function of AQPs in the kidney and their roles in different kidney diseases to reveal the prospects of AQPs in further basic and clinical studies.

Keywords: Knockout mouse; NDI; Polyuria; Urine concentrating mechanism; Water.

MeSH terms

Animals
Aquaporin 2
Aquaporins* / genetics
Kidney
Kidney Diseases*
Kidney Tubules, Proximal
Mice
Mice, Knockout

Substances

Aquaporin 2
Aquaporins