Prevalence of atherogenic dyslipidemia, related factors and level of lipid control in the general population of Galicia. GALIPEMIAS study
Clin Investig Arterioscler. 2023 Jul-Aug;35(4):178-184.
doi: 10.1016/j.arteri.2022.11.002.
Epub 2023 Jan 28.
[Article in
English,
Spanish]
Authors
Carlos Názara
1
, Rosa M Argüeso
2
, Juan Pedro-Botet
3
, Xavier Pintó
4
, Jesús Millán
5
, Marta Pena Seijo
6
, Pablo A Fernández
7
, M Eugenia Ameneiros
8
, Alberto Del Alamo
9
, Avelino Rodríguez
10
, José Antonio Díaz-Peromingo
11
, María Rosa Vázquez Freire
12
, Javier Muñiz
13
, Teresa R Pérez-Castro
13
, José Luis Díaz-Díaz
14
, Antonio Pose Reino
11
Affiliations
- 1 Centro de Atención Primaria de Marín, Marín, Pontevedra, España.
- 2 Servicio de Endocrinología y Nutrición, Hospital Universitario Lucus Augusti, Lugo, España.
- 3 Unidad de Lípidos y Riesgo Vascular, Servicio de Endocrinología y Nutrición, Hospital del Mar; Universitat Autònoma de Barcelona, Barcelona, España.
- 4 Unidad de Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario Bellvitge, CiberObn, Idibell, Fipec, Universidad de Barcelona, Barcelona, España.
- 5 Unidad de Lípidos, Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón; Facultad de Medicina Universidad Complutense, Madrid, España.
- 6 Fundación Pública Urgencias Sanitarias de Galicia-061, Santiago de Compostela, A Coruña, España.
- 7 Servicio de Endocrinología y Nutrición, Hospital de Montecelo, Pontevedra, España.
- 8 Servicio de Medicina Interna, Hospital Arquitecto Marcide, Ferrol, A Coruña, España.
- 9 Centro de Atención Primaria Novoa Santos, Ourense, España.
- 10 Servicio de Medicina Interna, Hospital Álvaro Cunqueiro, Vigo, Pontevedra, España.
- 11 Servicio de Medicina Interna, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, A Coruña, España.
- 12 Centro de Salud Os Rosales, A Coruña, España.
- 13 Universidad de A Coruña, Grupo de Investigación Cardiovascular (GRINCAR), Instituto Universitario de Ciencias de la Salud e Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, España.
- 14 Unidad de Lípidos y Riesgo Cardiovascular Servicio de Medicina Interna, Complejo Hospitalario Universitario de A Coruña, A Coruña, España. Electronic address: Jose.luis.diaz.diaz@sergas.es.
Abstract
Objectives:
GALIPEMIAS is a study designed to establish the prevalence of familial dyslipidemia in the general population of Galicia. The objective of the present study was to assess the prevalence of atherogenic dyslipidemia (AD), its relationship with other cardiovascular risk (CVR) factors, and the degree of lipid control.
Methods:
Cross-sectional study carried out in the general population over 18 years of age residing in Galicia and with a health card from the Galician Health Service (N=1,000). Selection of the sample by means of random sampling by conglomerates. The AD prevalence adjusted for age and sex and the related variables were analyzed.
Results:
The prevalence of AD adjusted for age and sex was 6.6% (95% CI: 5.0-8.3%). Arterial hypertension, altered basal glycemia, type 2 diabetes mellitus and cardiovascular disease were more frequent in subjects with AD than in the rest of the population. 47.5% of the subjects with AD had a high or very high CVR. Lipid-lowering drugs were received by 38.9% (30.5% statins) of the participants with AD (46.1% of those with high and 71.4% of those with very high CVR). 25.4% of the subjects with AD had target LDL-c levels, all of them with low or moderate CVR.
Conclusions:
The prevalence of AD in the general adult population of Galicia is not negligible, and it was related to several CVR factors and cardiovascular disease. Despite this, this lipid alteration was underdiagnosed and undertreated.
Keywords:
Atherogenic dyslipidemia; Atherosclerotic cardiovascular disease; Cardiovascular risk; Colesterol LDL; Dislipemia aterogénica; Enfermedad cardiovascular aterosclerótica; LDL cholesterol; Prevalence; Prevalencia; Riesgo cardiovascular.
Copyright © 2022. Publicado por Elsevier España, S.L.U.
MeSH terms
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Adolescent
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Adult
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Atherosclerosis* / diagnosis
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Cardiovascular Diseases* / epidemiology
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Cardiovascular Diseases* / etiology
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Cholesterol, HDL
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Cross-Sectional Studies
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Diabetes Mellitus, Type 2* / drug therapy
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Dyslipidemias* / drug therapy
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Humans
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Prevalence
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Risk Factors