Beyond housekeeping: autophagy regulates PKA signaling at synapses

Maeve Louise Coughlan; Sandra Maday

doi:10.1016/j.tins.2023.01.002

Beyond housekeeping: autophagy regulates PKA signaling at synapses

Trends Neurosci. 2023 Mar;46(3):167-169. doi: 10.1016/j.tins.2023.01.002. Epub 2023 Jan 28.

Authors

Maeve Louise Coughlan¹, Sandra Maday²

Affiliations

¹ Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
² Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: smaday@pennmedicine.upenn.edu.

Abstract

Autophagy modulates synaptic function and plasticity, but the molecular basis for this process is largely unknown. A recent tour de force study by Overhoff and colleagues identifies a novel role for autophagy in regulating PKA signaling at synapses to modulate the organization of the postsynaptic proteome and neuronal excitability.

Keywords: AMPAR; ATG5; PKA; proteome; synaptic plasticity; synaptic transmission.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Autophagy
Household Work
Humans
Neuronal Plasticity* / physiology
Receptors, AMPA* / metabolism
Synapses / physiology
Synaptic Transmission / physiology

Substances

Receptors, AMPA

Grants and funding

R01 NS110716/NS/NINDS NIH HHS/United States