Ca2+-calmodulin signalling at the host-pathogen interface

Abstract

Multiple eukaryotic cell processes are modulated by calcium ions (Ca²⁺). As such, Ca²⁺ is emerging as a crucial regulator of innate immunity in multicellular organisms. In particular, recent studies have identified roles of Ca²⁺ signalling at the host-bacteria interface. Following microbial exposure, Ca²⁺ signals mobilised from the extracellular milieu or intracellular stores are transduced into cell physiological responses. However, during infection with host-adapted pathogens, Ca²⁺ signals are often atypical, due to the activities of virulence factors, with varied consequences for both the pathogen and the host cell. In this review, we describe the Ca²⁺-dependent host factors regulating antibacterial immunity, in addition to bacterial effectors that promote, inhibit, or co-opt Ca²⁺-calmodulin signalling to promote infection.