Osteocalcin serum concentrations and markers of energetic metabolism in pediatric patients. Systematic review and metanalysis

Silvia Rodríguez-Narciso; Raigam Jafet Martínez-Portilla; Iris Paola Guzmán-Guzmán; Gabriela Careaga-Cárdenas; Brenda Jazmin Rubio-Navarro; Luis Fernando Barba-Gallardo; Rodolfo Delgadillo-Castañeda; José Rafael Villafan-Bernal

doi:10.3389/fped.2022.1075738

Osteocalcin serum concentrations and markers of energetic metabolism in pediatric patients. Systematic review and metanalysis

Front Pediatr. 2023 Jan 12:10:1075738. doi: 10.3389/fped.2022.1075738. eCollection 2022.

Authors

Silvia Rodríguez-Narciso¹, Raigam Jafet Martínez-Portilla^{2

3}, Iris Paola Guzmán-Guzmán⁴, Gabriela Careaga-Cárdenas⁵, Brenda Jazmin Rubio-Navarro⁵, Luis Fernando Barba-Gallardo⁵, Rodolfo Delgadillo-Castañeda⁶, José Rafael Villafan-Bernal^{3

7

8}

Affiliations

¹ Basic Sciences Center, Autonomous University of Aguascalientes, Aguascalientes, Mexico.
² Clinical Research Division, Evidence-Based Medicine Department, National Institute of Perinatology, Mexico City, Mexico.
³ Molecular and Maternal-Fetal Medicine, Iberoamerican Research Network in Translational, Mexico City, Mexico.
⁴ Faculty of Chemical-Biological Sciences, Universidad Autónoma de Guerrero, Chilpancingo, Mexico.
⁵ Center for Health Sciences, Autonomous University of Aguascalientes, Aguascalientes, Mexico.
⁶ Department of Pediatrics, Centenario Hospital Miguel Hidalgo, ISSEA Aguascalientes, Aguascalientes, Mexico.
⁷ Investigador por México, National Council of Science and Technology (CONACYT), Mexico City, Mexico.
⁸ Laboratory of Immunogenomics and Metabolic Diseases, Mexican National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico.

Abstract

Background: Osteocalcin plays a role in glucose metabolism in mice, but its relevance in human energetic metabolism is controversial. Its relationship with markers of energetic metabolism in the pediatric population has not been systematically addressed in infants and adolescents.

Objective: This study aims to assess the mean differences between tOC, ucOC, and cOC among healthy children and children with type 1 or type 2 diabetes (T1D or T2D) and the correlation of these bone molecules with metabolic markers.

Methods: A systematic review and metanalysis were performed following PRISMA criteria to identify relevant observational studies published in English and Spanish using PubMed, Scopus, EBSCO, and Web of Science databases. The risk of bias was assessed using New Castle-Ottawa scale. Effect size measures comprised standardized mean difference (SMD) and Pearson correlations. Heterogeneity and meta-regressions were performed.

Results: The 20 studies included were of high quality and comprised 3,000 pediatric patients who underwent tOC, cOC, or ucOC measurements. Among healthy subjects, there was a positive correlation of ucOC with WC and weight, a positive correlation of tOC with FPG, HDL-c, WC, height, and weight, and a negative correlation between tOC and HbA1c. Among diabetic subjects, a negative correlation of ucOC with HbA1c and glycemia in both T1D and T2D was found and a negative correlation between tOC and HbA1c in T1D but not in T2D. The ucOC concentrations were lower in T2D, T1D, and patients with abnormal glucose status than among controls. The serum concentrations of tOC concentrations were lower among T1D than in controls. The patient's age, altitude, and HbA1c influenced the levels of serum tOC.

Conclusion: Osteocalcin is involved in energy metabolism in pediatric subjects because it is consistently related to metabolic and anthropometric parameters.

Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42019138283.

Keywords: energetic metabolism; glucose - insulin; osteocalcin; pediatric patient; systematic review & meta-analysis.

Publication types

Review

Grants and funding

We appreciate the funding of the Autonomous University of Aguascalientes during the development of this research.