Trends in pediatric community-onset Staphylococcus aureus antibiotic susceptibilities over a five-year period in a multihospital health system

Erica C Prochaska; Shaoming Xiao; Pranita D Tamma; Anna Sick-Samuels; Christina Schumacher; Avinash Gadala; Karen C Carroll; Aaron M Milstone

doi:10.1017/ash.2022.370

Trends in pediatric community-onset Staphylococcus aureus antibiotic susceptibilities over a five-year period in a multihospital health system

Antimicrob Steward Healthc Epidemiol. 2023 Jan 17;3(1):e12. doi: 10.1017/ash.2022.370. eCollection 2023.

Authors

Erica C Prochaska¹, Shaoming Xiao¹, Pranita D Tamma¹, Anna Sick-Samuels^{1

2}, Christina Schumacher³, Avinash Gadala², Karen C Carroll⁴, Aaron M Milstone^{1

2}

Affiliations

¹ Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
² Department of Hospital Epidemiology and Infection Control, Johns Hopkins Health System, Baltimore, Maryland.
³ Division of General Pediatrics, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
⁴ Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Abstract

The epidemiology of community-onset Staphylococcus aureus infections is evolving. We performed a multihospital, retrospective study of pediatric community-onset S. aureus susceptibilities between 2015 and 2020. Oxacillin and clindamycin susceptibility remained lower at 67% and 75%, respectively. Tetracycline and trimethoprim-sulfamethoxazole susceptibility remained high at >90%. Oxacillin susceptibility was highest in invasive infections.