The role of Hippo pathway in ferroptosis

Jiangxia Xiang; Mengmeng Jiang; Xing Du

doi:10.3389/fonc.2022.1107505

The role of Hippo pathway in ferroptosis

Front Oncol. 2023 Jan 11:12:1107505. doi: 10.3389/fonc.2022.1107505. eCollection 2022.

Authors

Jiangxia Xiang¹, Mengmeng Jiang², Xing Du^{3

4}

Affiliations

¹ Department of Traumatology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.
² Department of Medical Oncology, The Third Central Hospital of Tianjin, Tianjin, China.
³ Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
⁴ Orthopedic Laboratory of Chongqing Medical University, Chongqing, China.

Abstract

The role of Hippo pathway in ferroptosis The Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and the antioxidant system. This article elaborates the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors.

Keywords: Hippo pathway; ROS; YAP; ferroptosis; iron metabolism.

Publication types

Review

Grants and funding

This work was funded by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0972, cstc2020jcyj-msxmX0541), the Basic Research and Frontier Exploration Project of Yuzhong District of Chongqing (20200142), and the Natural Science Foundation of Tianjin (20JCQNJC01400).