Gut microbiota and calcium balance

Jiali Wang; Shuang Wu; Yinshan Zhang; Jiao Yang; Zhongliang Hu

doi:10.3389/fmicb.2022.1033933

Gut microbiota and calcium balance

Front Microbiol. 2022 Dec 20:13:1033933. doi: 10.3389/fmicb.2022.1033933. eCollection 2022.

Authors

Jiali Wang¹, Shuang Wu², Yinshan Zhang², Jiao Yang³, Zhongliang Hu⁴

Affiliations

¹ Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, BeiJing, China.
² Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
³ Department of Pathology, Changsha Medical School, Changsha, Hunan, China.
⁴ Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Microorganisms living on the surface and inside the human body play an important role in the physiological activities of the human body. The largest microecosystem in the human body is the gut microbiome. Calcium disorders are found in many diseases. For example, patients with chronic renal insufficiency present with secondary hyperparathyroidism, which is caused by a calcium imbalance in the body. In addition, calcium dysregulation may affect lipid metabolism in the liver through the calmodulator pathway, leading to cirrhosis, etc. Currently, a considerable number of probiotics have been proven to enhance the body's absorption of calcium. This paper reviews the effects of intestinal flora and related factors such as short-chain fatty acids, estrogen, immune factors and vitamin D on calcium balance.

Keywords: bone metabolism; estrogen; gut microbiota; immune factors; liver; short-chain fatty acids; vitamin D.

Publication types

Review