P53 protein and the diseases in central nervous system

Li Lei; Qixiong Lu; Guifang Ma; Tao Li; Jiahong Deng; Weijia Li

doi:10.3389/fgene.2022.1051395

P53 protein and the diseases in central nervous system

Front Genet. 2023 Jan 9:13:1051395. doi: 10.3389/fgene.2022.1051395. eCollection 2022.

Authors

Li Lei¹, Qixiong Lu¹, Guifang Ma², Tao Li¹, Jiahong Deng², Weijia Li¹

Affiliations

¹ The Affiliated Hospital of Kunming University of Science and Technology, The Department of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
² Department of Ear, Nose and Throat (ENT) and Head and Neck (HN) Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Abstract

P53 protein is the product of P53 gene, which is a well acknowledged tumor suppressor gene. The function of P53 and the relevant mechanisms of anti-neoplasm have raised the interest of researchers since many years ago. It is demonstrated that P53 is a basic cell cycle regulator and a strong inhibitor for versatile cancers in humans. However, most research focuses on other organs and systems instead of the central nervous system (CNS). In fact, in recent years, more and more studies have been suggesting that P53 plays a significant role in multiple CNS tumors and other diseases and disorders such as cerebral stroke and neurodegenerative diseases. In this work, we mainly reviewed the P53's relationship with CNS tumors, cerebral stroke and neurodegenerative diseases, together with the relevant mechanisms, aiming to summarize the research achievements and providing new insight to the future study on diseases in CNS.

Keywords: P53; apoptosis; cerebral stroke; ferroptosis; gliomas; neurodegenerative diseases; neuroinflammation.

Publication types

Review

Grants and funding

This work was funded by the National Natural Science Foundation of China (Grant NO. 82001278), The Fund for Young Doctors with the First People’s Hospital of Yunnan Province (Grant NO. KHBS-2020-014), Yunnan Fundamental Research Projects (Grant NO. 202101AU070106), and Joint Projects of Yunnan Provincial Science and Technology Department and Kunming Medical University for Applied Basic Research (Grant NO. 202101AY070001-252).