Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism

Zhaofeng Liang; Yumeng Xu; Yue Zhang; Xinyi Zhang; Jiajia Song; Jianhua Jin; Hui Qian

doi:10.3389/fphar.2022.1078090

Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism

Front Pharmacol. 2023 Jan 12:13:1078090. doi: 10.3389/fphar.2022.1078090. eCollection 2022.

Authors

Zhaofeng Liang^{1

2}, Yumeng Xu², Yue Zhang², Xinyi Zhang², Jiajia Song², Jianhua Jin¹, Hui Qian^{1

2}

Affiliations

¹ Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Chang Zhou, China.
² Department of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.

Abstract

Gastric cancer (GC) is the fourth most common malignant cancer and is a life-threatening disease worldwide. Phytochemicals have been shown to be a rational, safe, non-toxic, and very promising approach to the prevention and treatment of cancer. It has been found that phytochemicals have protective effects against GC through inhibiting cell proliferation, inducing apoptosis and autophagy, suppressing cell invasion and migration, anti-angiogenesis, inhibit Helicobacter pylori infection, regulating the microenvironment. In recent years, the role of phytochemicals in the occurrence, development, drug resistance and prognosis of GC has attracted more and more attention. In order to better understand the relationship between phytochemicals and gastric cancer, we briefly summarize the roles and functions of phytochemicals in GC tumorigenesis, development and prognosis. This review will probably help guide the public to prevent the occurrence and development of GC through phytochemicals, and develop functional foods or drugs for the prevention and treatment of gastric cancer.

Keywords: gastric cancer; mechanisms; phytochemicals; prevention; treatment.

Publication types

Review

Grants and funding

This work was supported by National Natural Science Foundation of China (no. 81602883), project of social development in Zhenjiang (No. SH2021045), Technology Development Project of Jiangsu University (20220516), the Foundation for excellent young teachers of Jiangsu University.