Utility of serum amyloid A as a potential prognostic biomarker of aneurysmal subarachnoid hemorrhage

Zhongbo Sun; Yaqiang Li; Fu Chang; Ke Jiang

doi:10.3389/fneur.2022.1099391

Utility of serum amyloid A as a potential prognostic biomarker of aneurysmal subarachnoid hemorrhage

Front Neurol. 2023 Jan 12:13:1099391. doi: 10.3389/fneur.2022.1099391. eCollection 2022.

Authors

Zhongbo Sun¹, Yaqiang Li^{1

2}, Fu Chang¹, Ke Jiang¹

Affiliations

¹ Department of Neurosurgery, First Affiliated Hospital of Anhui University of Science and Technology (First People's Hospital of Huainan), Huainan, China.
² Department of Neurology, People's Hospital of Lixin County, Bozhou, China.

Abstract

Objectives: Inflammation plays a vital role in the aneurysmal subarachnoid hemorrhage (aSAH), while serum amyloid A (SAA) has been identified as an inflammatory biomarker. The present study aimed to elucidate the relationship between SAA concentrations and prognosis in aSAH.

Methods: From prospective analyses of patients admitted to our department between March 2016 and August 2022, aSAH patients with complete medical records were evaluated. Meanwhile, the healthy control group consisted of the age and sex matched individuals who came to our hospital for healthy examination between March 2018 and August 2022. SAA level was measured by enzyme-linked immunosorbent assay kit (Invitrogen Corp). The Glasgow Outcome Scale (GOS) was used to classify patients into good (GOS score of 4 or 5) and poor (GOS score of 1, 2, or 3) outcome.

Results: 456 patients were enrolled in the study, thereinto, 200 (43.86%) patients had a poor prognosis at the 3-months follow-up. Indeed, the SAA of poor outcome group were significantly increased compared to good outcome group and healthy control group [36.44 (32.23-41.00) vs. 28.99 (14.67-34.12) and 5.64 (3.43-7.45), P < 0.001]. In multivariate analyses, SAA served for independently predicting the poor outcome after aICH at 3 months [OR:1.129 (95% CI, 1.081-1.177), P < 0.001]. After adjusting the underlying confounding factors, the odds ratio (OR) of depression after aSAH was 2.247 (95% CI: 1.095-4.604, P = 0.021) for the highest tertile of SAA relative to the lowest tertile. With an AUC of 0.807 (95% CI, 0.623-0.747), SAA demonstrated an obviously better discriminatory ability relative to CRP, WBC, and IL-6. SAA as an indicator for predicting poor outcome after aSAH had an optimal cut-off value of 30.28, and the sensitivity and specificity were 61.9 and 78.7%, respectively.

Conclusions: Elevated level of SAA was associated with poor outcome at 3 months, suggesting that SAA might be a useful inflammatory markers to predict prognosis after aSAH.

Keywords: SAA; aSAH; aneurysmal subarachnoid hemorrhage; inflammation; serum amyloid A.

Grants and funding

This work was supported by the Huainan Key Scientific Research Project (2018A369) and the Natural Science Foundation of Health Commission of Anhui Province (2016qk1108).