Copolymerized carbon nitride nanoparticles for near-infrared II photoacoustic-guided synergistic photothermal/radiotherapy

Min Wu; Yuxin Huang; Xiaoyu Huang; Fu Wang; Xunbin Wei

doi:10.3389/fchem.2023.1124559

Copolymerized carbon nitride nanoparticles for near-infrared II photoacoustic-guided synergistic photothermal/radiotherapy

Front Chem. 2023 Jan 13:11:1124559. doi: 10.3389/fchem.2023.1124559. eCollection 2023.

Authors

Min Wu¹, Yuxin Huang², Xiaoyu Huang², Fu Wang², Xunbin Wei³

Affiliations

¹ Department of Plastic and Reconstructive Surgery, School of Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
² School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
³ Biomedical Engineering Department, Peking University, Beijing, China.

Abstract

Nanotheranostic agents that integrate diagnosis and treatment are promising for precision medicine, but they encounter some obstacles such as penetration depth and efficiency. In this study, novel carbon nitride-rose bengal nanoparticles (CN-RB NPs) with a graphite carbon nitride skeleton were synthesized by one-step thermal copolymerization. The enhanced absorption in the near-infrared-II region (NIR-II) endows CN-RB NPs with an excellent photothermal effect under 1064 nm laser irradiation, as well as an obvious photoacoustic signal for imaging in vivo. Interestingly, due to the introduced iodine element, CN-RB NPs exhibit enhanced radiation therapy, indicating that CN-RB NPs can achieve ideal therapeutic outcome through collaborative photothermal/radiation therapy under the guidance of NIR-II photoacoustic imaging. Moreover, CN-RB NPs demonstrate minimal side effects and long-term biological stability after 14 days. Therefore, the proposed new multifunctional nano-platform CN-RB NPs hold great potential in the application of deep therapeutics.

Keywords: copolymerized carbon nitride nanoparticles; near-infrared II; photoacoustic; photothermal therapy; radiotherapy.

Grants and funding

This research was funded by the National Key Research and Development Program of China, grant number 2019YFC1604600;the Shenzhen Science and Technology Innovation Grants, grant number JCYJ20200109115633343; and the Medicine and Engineering Cross Research Foundation of Shanghai Jiao Tong University, grant number YG2022QN047.