Economical downstream processing of microbial polyunsaturated fatty acids

Peng-Wei Huang; Chun-Xiao Yan; Xiao-Man Sun; He Huang

doi:10.1016/j.tibtech.2023.01.001

Economical downstream processing of microbial polyunsaturated fatty acids

Trends Biotechnol. 2023 Jul;41(7):857-859. doi: 10.1016/j.tibtech.2023.01.001. Epub 2023 Jan 26.

Authors

Peng-Wei Huang¹, Chun-Xiao Yan¹, Xiao-Man Sun², He Huang³

Affiliations

¹ School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, People's Republic of China.
² School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, People's Republic of China. Electronic address: xiaomansun@njnu.edu.cn.
³ School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, People's Republic of China; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, People's Republic of China. Electronic address: huangh@njnu.edu.cn.

PMID: 36709095
DOI: 10.1016/j.tibtech.2023.01.001

Abstract

Polyunsaturated fatty acids (PUFAs) are important nutrients for humans and animals. Microorganisms, such as yeast, filamentous fungi, and microalgae, have successfully been modified to produce PUFAs. Apart from strain improvement and fermentation optimization, efficient and cost-effective downstream processing will determine whether production can advance from the laboratory to the factory.

Keywords: downstream processing; lipid extraction; lipid refining; polyunsaturated fatty acids.

MeSH terms

Animals
Fatty Acids
Fatty Acids, Unsaturated*
Fermentation
Fungi / genetics
Humans
Microalgae*
Saccharomyces cerevisiae

Substances

Fatty Acids, Unsaturated
Fatty Acids