The combinational nano-immunotherapy of ferumoxytol and poly(I:C) inhibits melanoma via boosting anti-angiogenic immunity

Yunuo Zheng; Bo Jiang; Hongmei Guo; Zhonghai Zhang; Bo Chen; Zhengkui Zhang; Shaoyuan Wu; Jiaojiao Zhao

doi:10.1016/j.nano.2023.102658

The combinational nano-immunotherapy of ferumoxytol and poly(I:C) inhibits melanoma via boosting anti-angiogenic immunity

Nanomedicine. 2023 Apr:49:102658. doi: 10.1016/j.nano.2023.102658. Epub 2023 Jan 25.

Authors

Yunuo Zheng¹, Bo Jiang², Hongmei Guo³, Zhonghai Zhang⁴, Bo Chen⁵, Zhengkui Zhang⁶, Shaoyuan Wu⁷, Jiaojiao Zhao⁸

Affiliations

¹ Jiangsu Key Laboratory of Phylogenomics and Comparative Genomics, Jiangsu Joint International Center of Genomics, School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
² Jiangsu Key Laboratory of Phylogenomics and Comparative Genomics, Jiangsu Joint International Center of Genomics, School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China; Department of Urology, Xuzhou Central Hospital, Xuzhou 221009, China.
³ Department of Ultrasonography, Weinan Maternal and Child Health Hospital, Weinan 714000, Shaanxi, China.
⁴ Jiangsu Key Laboratory of Phylogenomics and Comparative Genomics, Jiangsu Joint International Center of Genomics, School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China; Department of Physiology, Xuzhou Medical University, Xuzhou 221004, China.
⁵ Institute of Materials Science and Devices, School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.
⁶ Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou 221002, China. Electronic address: zkzhang@xzhmu.edu.cn.
⁷ Jiangsu Key Laboratory of Phylogenomics and Comparative Genomics, Jiangsu Joint International Center of Genomics, School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China. Electronic address: shaoyuanwu@post.harvard.edu.
⁸ Jiangsu Key Laboratory of Phylogenomics and Comparative Genomics, Jiangsu Joint International Center of Genomics, School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China. Electronic address: jiaojiaozhao@jsnu.edu.cn.

PMID: 36708910
DOI: 10.1016/j.nano.2023.102658

Abstract

Angiogenesis plays a key role in the progression and metastasis of melanoma, and the pro-angiogenic effect of macrophages is one major reason for the failure of current anti-angiogenic therapies. Here, a nano-immunotherapy combining ferumoxytol and poly(I:C) (ferumoxytol/poly(I:C)) has been developed to boost the anti-angiogenic activities of macrophages to inhibit melanoma. Our findings demonstrated that ferumoxytol/poly(I:C) was a highly efficacious anti-tumor therapy with limited toxicity. Both in vivo and in vitro experiments indicated that this combination was successful in impeding angiogenesis. Ferumoxytol/poly(I:C) was demonstrated to reduce the viability of endothelial cells, thus hindering tube formation. Particularly, ferumoxytol/poly(I:C) was able to polarize macrophages to the M1 phenotype and decrease the expression of vascular endothelial growth factor, which in turn amplified the anti-angiogenic properties of ferumoxytol/poly(I:C). This combination of ferumoxytol/poly(I:C) nano-immunotherapy enriches the anti-angiogenic therapeutic nature of ferumoxytol and will shed new light on the treatment of melanoma.

Keywords: Anti-angiogenesis; Ferumoxytol/poly(I:C); Macrophage polarization; Nano-immunotherapy; Superparamagnetic iron oxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents* / therapeutic use
Endothelial Cells / metabolism
Ferrosoferric Oxide / pharmacology
Ferrosoferric Oxide / therapeutic use
Humans
Melanoma* / pathology
Penicillins / therapeutic use
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors

Substances

Ferrosoferric Oxide
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Penicillins
Anti-Infective Agents