Emerging plasmonic nanoparticles and their assemblies for cancer radiotherapy

Ying Wu; Kang Zhu; Xuan Zhang; Wei Du; Jibin Song; Huanghao Yang

doi:10.1016/j.addr.2023.114710

Emerging plasmonic nanoparticles and their assemblies for cancer radiotherapy

Adv Drug Deliv Rev. 2023 Mar:194:114710. doi: 10.1016/j.addr.2023.114710. Epub 2023 Jan 25.

Authors

Ying Wu¹, Kang Zhu¹, Xuan Zhang², Wei Du², Jibin Song³, Huanghao Yang⁴

Affiliations

¹ State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 10010, PR China.
² MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116, PR China.
³ State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 10010, PR China. Electronic address: jibin.song@buct.edu.cn.
⁴ MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116, PR China. Electronic address: hhyang@fzu.edu.cn.

PMID: 36708774
DOI: 10.1016/j.addr.2023.114710

Abstract

Plasmonic nanoparticles and their assemblies have been widely used in biosensing, optical imaging, and biomedicine over the past few decades. Especially in the field of radiotherapy, the physicochemical properties of high-Z plasmonic nanomaterials endow them with the ability to sensitize radiotherapy. Compared with single particles, the assembled structure with tunable properties leads to versatile applications in drug delivery and cancer treatment. In this review, we focus on plasmonic nanoparticles and their assemblies for cancer radiotherapy. First, the sensitization mechanism of plasmonic radiosensitizers is briefly introduced. Subsequently, the recent progress in cancer radiotherapy is systematically discussed according to the structure and shape classification. Finally, the current challenges and future perspectives in this field are also discussed in detail.

Keywords: Assemblies; Optical imaging; Plasmonic nanoparticles; Radiosensitizer; Radiotherapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Metal Nanoparticles* / chemistry
Nanoparticles*
Nanostructures* / chemistry
Neoplasms* / therapy
Optical Imaging