A mesoporous MnO2-based nanoplatform with near infrared light-controlled nitric oxide delivery and tumor microenvironment modulation for enhanced antitumor therapy

Hai-Lin Zhang; Yi Wang; Qi Tang; Bing Ren; Shi-Ping Yang; Jin-Gang Liu

doi:10.1016/j.jinorgbio.2023.112133

A mesoporous MnO₂-based nanoplatform with near infrared light-controlled nitric oxide delivery and tumor microenvironment modulation for enhanced antitumor therapy

J Inorg Biochem. 2023 Apr:241:112133. doi: 10.1016/j.jinorgbio.2023.112133. Epub 2023 Jan 20.

Authors

Hai-Lin Zhang¹, Yi Wang¹, Qi Tang¹, Bing Ren¹, Shi-Ping Yang², Jin-Gang Liu³

Affiliations

¹ Key Laboratory for Advanced Materials, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
² Key Lab of Resource Chemistry of MOE & Shanghai Key Lab of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, P. R. China.
³ Key Laboratory for Advanced Materials, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China. Electronic address: liujingang@ecust.edu.cn.

PMID: 36708626
DOI: 10.1016/j.jinorgbio.2023.112133

Abstract

A hollow mesoporous manganese dioxide-based (H-MnO₂) multifunctional nanoplatform, H-MnO₂ @AFIPB@PDA@Ru-NO@FA (MAPRF NPs), was prepared for synergistic cancer treatment, in which a histone deacetylase inhibitor AFIPB was loaded in its hollow cavity and a ruthenium nitrosyl donor (Ru-NO) and a folic acid (FA) targeting group were covalently decorated on its covered polydopamine (PDA) layer. The MAPRF NPs showed tumor microenvironment (TME)-responsive properties of depletion of glutathione (GSH) to disrupt the antioxidant defense system and on-demand drug delivery. And the released Mn²⁺ further catalyzed the decomposition of endogenous H₂O₂ to produce highly toxic hydroxyl radicals (·OH) for enhanced chemodynamic therapy (CDT). Furthermore, upon 808 nm light irradiation MAPRF NPs exhibited controlled nitric oxide (NO) delivery and simultaneously produced significant photothermal effect. Consequently, MAPRF NPs showed high mortality toward cancer cells in the presence of 808 nm light irradiation. This work provides a paradigm of multimodal synergistic therapy that combines NO-based gas therapy with TME modulation for efficient antitumor therapy.

Keywords: Fenton-like reaction; Manganese dioxide; Nitric oxide delivery; Ruthenium nitrosyl; Synergistic therapy; Tumor microenvironment modulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrogen Peroxide
Manganese Compounds*
Nitric Oxide* / pharmacology
Oxides
Tumor Microenvironment

Substances

Nitric Oxide
Manganese Compounds
Hydrogen Peroxide
Oxides