MicroRNA schizophrenia: Etiology, biomarkers and therapeutic targets

Heng-Chang Zhang; Yang Du; Lei Chen; Zeng-Qiang Yuan; Yong Cheng

doi:10.1016/j.neubiorev.2023.105064

MicroRNA schizophrenia: Etiology, biomarkers and therapeutic targets

Neurosci Biobehav Rev. 2023 Mar:146:105064. doi: 10.1016/j.neubiorev.2023.105064. Epub 2023 Jan 24.

Authors

Heng-Chang Zhang¹, Yang Du², Lei Chen², Zeng-Qiang Yuan³, Yong Cheng⁴

Affiliations

¹ Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China.
² Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Minzu University of China, Beijing, China.
³ Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China; Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
⁴ Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China; Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Minzu University of China, Beijing, China; Institute of National Security, Minzu University of China, Beijing, China. Electronic address: yongcheng@muc.edu.cn.

PMID: 36707012
DOI: 10.1016/j.neubiorev.2023.105064

Abstract

The three sets of symptoms associated with schizophrenia-positive, negative, and cognitive-are burdensome and have serious effects on public health, which affects up to 1% of the population. It is now commonly believed that in addition to the traditional dopaminergic mesolimbic pathway, the etiology of schizophrenia also includes neuronal networks, such as glutamate, GABA, serotonin, BDNF, oxidative stress, inflammation and the immune system. Small noncoding RNA molecules called microRNAs (miRNAs) have come to light as possible participants in the pathophysiology of schizophrenia in recent years by having an impact on these systems. These small RNAs regulate the stability and translation of hundreds of target transcripts, which has an impact on the entire gene network. There may be improved approaches to treat and diagnose schizophrenia if it is understood how these changes in miRNAs alter the critical related signaling pathways that drive the development and progression of the illness.

Keywords: 5-HT; BDNF; Dopamine; GABA; Glutamate; Inflammation and immunity; MiRNA; Oxidative stress; Schizophrenia; Therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Gene Regulatory Networks
Humans
MicroRNAs* / genetics
MicroRNAs* / metabolism
MicroRNAs* / therapeutic use
Schizophrenia* / drug therapy
Signal Transduction

Substances

MicroRNAs
Biomarkers