Recent advances, opportunities and challenges in cybergenetic identification and control of biomolecular networks

Gianpio Caringella; Lucia Bandiera; Filippo Menolascina

doi:10.1016/j.copbio.2023.102893

Recent advances, opportunities and challenges in cybergenetic identification and control of biomolecular networks

Curr Opin Biotechnol. 2023 Apr:80:102893. doi: 10.1016/j.copbio.2023.102893. Epub 2023 Jan 25.

Authors

Gianpio Caringella¹, Lucia Bandiera², Filippo Menolascina³

Affiliations

¹ School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh EH9 3DW, UK.
² School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh EH9 3DW, UK; Centre for Engineering Biology, The University of Edinburgh, Edinburgh EH9 3BF, UK.
³ School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh EH9 3DW, UK; Centre for Engineering Biology, The University of Edinburgh, Edinburgh EH9 3BF, UK. Electronic address: filippo.menolascina@ed.ac.uk.

PMID: 36706519
DOI: 10.1016/j.copbio.2023.102893

Abstract

Cybergenetics is a new area of research aimed at developing digital and biological controllers for living systems. Synthetic biologists have begun exploiting cybergenetic tools and platforms to both accelerate the development of mathematical models and develop control strategies for complex biological phenomena. Here, we review the state of the art in cybergenetic identification and control. Our aim is to lower the entry barrier to this field and foster the adoption of methods and technologies that will accelerate the pace at which Synthetic Biology progresses toward applications.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Models, Theoretical*
Synthetic Biology*