Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models

Ariadni Bella; Alba M Diego; David P Finn; Michelle Roche

doi:10.3389/fpain.2022.1106143

Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models

Front Pain Res (Lausanne). 2023 Jan 10:3:1106143. doi: 10.3389/fpain.2022.1106143. eCollection 2022.

Authors

Ariadni Bella^{1

2

3}, Alba M Diego^{2

3

4}, David P Finn^{2

3

4}, Michelle Roche^{1

2

3}

Affiliations

¹ Physiology, School of Medicine, University of Galway, Galway, Ireland.
² Centre for Pain Research, University of Galway, Galway, Ireland.
³ Galway Neuroscience Centre, University of Galway, Galway, Ireland.
⁴ Pharmacology and Therapeutics, School of Medicine, University of Galway, Galway, Ireland.

Abstract

Chronic post-surgical pain affects up to 85% of individuals depending on the type of surgery, the extent of inflammation, tissue and/or nerve damage. Pre-surgical stress is associated with greater pain intensity, prolonged recovery and is one of the main risk factors for the development of chronic post-surgical pain. Clinically valid animal models provide an important means of examining the mechanisms underlying the effects of stress on post-surgical pain and identifying potential novel therapeutic targets. This review discusses the current data from preclinical animal studies examining the effect of stress on post-surgical pain, the potential underlying mechanisms and gaps in the knowledge that require further investigation.

Keywords: allodynia; anxiety; depression; neuroimmune; stress; surgery; von frey.

Publication types

Review

Grants and funding

This research was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skltodowska–Curie grant agreement grant no. 955684.