Coexistence of anti-MDA5 and anti-PL-7 in a patient with dermatomyositis: A case report

Hongyan Fu; Shaofeng Sun; Hong Zhang; Shuhong Chi; Weirong Ma; Guilan Yang; Juan Chen

doi:10.1002/ccr3.6840

Coexistence of anti-MDA5 and anti-PL-7 in a patient with dermatomyositis: A case report

Clin Case Rep. 2023 Jan 23;11(1):e6840. doi: 10.1002/ccr3.6840. eCollection 2023 Jan.

Authors

Hongyan Fu^{1

2}, Shaofeng Sun¹, Hong Zhang¹, Shuhong Chi³, Weirong Ma¹, Guilan Yang¹, Juan Chen¹

Affiliations

¹ Department of Pulmonary and Critical Care Medicine General Hospital of Ningxia Medical University Yinchuan, Ningxia China.
² Ningxia Medical University Ningxia China.
³ Department of Rheumatology General Hospital of Ningxia Medical University Yinchuan, Ningxia China.

Abstract

Coexisting anti-MDA5 and anti-PL-7 antibodies are extremely rare. Anti-MDA5 is associated with rapidly progressive interstitial lung disease (RP-ILD), while anti-PL-7 is often associated with chronic or subacute ILD and better outcomes than RP-ILD. We report a 41-year-old woman diagnosed with dermatomyositis (DM)-associated ILD positive for anti-MDA5 and anti-PL-7.

Keywords: anti‐MDA5; anti‐PL‐7; dermatomyositis; interstitial lung disease; myositis‐specific autoantibodies.

Publication types

Case Reports