Mechanistic insight: Linking cardiovascular complications of inflammatory bowel disease

Hirushi Kumarapperuma; Ran Wang; Peter J Little; Danielle Kamato

doi:10.1016/j.tcm.2023.01.002

Mechanistic insight: Linking cardiovascular complications of inflammatory bowel disease

Trends Cardiovasc Med. 2024 Apr;34(3):203-211. doi: 10.1016/j.tcm.2023.01.002. Epub 2023 Jan 24.

Authors

Hirushi Kumarapperuma¹, Ran Wang², Peter J Little³, Danielle Kamato⁴

Affiliations

¹ School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland 4102, Australia; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.
² Mater Research Institute, The University of Queensland, Translational Research Institute, Queensland 4102, Australia.
³ School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland 4102, Australia; Department of Pharmacy, Xinhua College of Sun Yat-sen University, Tianhe District, Guangzhou 510520, China.
⁴ School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland 4102, Australia; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia; School of Environment and Science, Griffith University, Nathan, Queensland 4111, Australia. Electronic address: d.kamato@griffith.edu.au.

PMID: 36702388
DOI: 10.1016/j.tcm.2023.01.002

Abstract

Cardiovascular diseases (CVD) are the leading cause of mortality worldwide despite an aggressive reduction of traditional cardiovascular risk factors. Underlying inflammatory conditions such as inflammatory bowel disease (IBD) increase the risk of developing CVD. A broad understanding of the underlying pathophysiological processes between IBD and CVD is required to treat and prevent cardiovascular events in patients with IBD. This review highlights the commonality between IBD and CVD, including dysregulated immune response, genetics, environmental risk factors, altered gut microbiome, stress, endothelial dysfunction and abnormalities, to shed light on an essential area of modern medicine.

Keywords: Atherosclerosis; Endothelial dysfunction; Immune response; Inflammatory cytokines; Microbiome.

Publication types

Review

MeSH terms

Cardiovascular Diseases* / diagnosis
Cardiovascular Diseases* / epidemiology
Cardiovascular Diseases* / etiology
Gastrointestinal Microbiome*
Heart Disease Risk Factors
Humans
Inflammatory Bowel Diseases* / complications
Inflammatory Bowel Diseases* / diagnosis
Inflammatory Bowel Diseases* / therapy
Vascular Diseases*