The role of Th17 cells in inflammatory bowel disease and the research progress

Lu Chen; Guangcong Ruan; Yi Cheng; Ailin Yi; Dongfeng Chen; Yanling Wei

doi:10.3389/fimmu.2022.1055914

The role of Th17 cells in inflammatory bowel disease and the research progress

Front Immunol. 2023 Jan 9:13:1055914. doi: 10.3389/fimmu.2022.1055914. eCollection 2022.

Authors

Lu Chen¹, Guangcong Ruan¹, Yi Cheng¹, Ailin Yi¹, Dongfeng Chen¹, Yanling Wei¹

Affiliation

¹ Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Abstract

Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important parts of intestinal immunity and regulators of Th17 cellular immunity. Th17 cell differentiation is regulated by intestinal bacteria and cytokines, and Th17 cells regulate the intestinal mucosal immune microenvironment by secreting cytokines, such as IL-17, IL-21, and IL-26. Solid evidence showed that, regarding the treatment of IBD by targeting Th17 cells, the therapeutic effect of different biological agents varies greatly. Fecal bacteria transplantation (FMT) in the treatment of IBD has been a popular research topic in recent years and is safe and effective with few side effects. To further understand the role of Th17 cells in the progression of IBD and associated therapeutic prospects, this review will discuss the progress of related research on Th17 cells in IBD by focusing on the interaction and immune regulation between Th17 cells and gut microbiota.

Keywords: T helper 17 cells; gut microbiota; inflammatory; inflammatory bowel disease; intestinal fibrosis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytokines
Humans
Inflammation
Inflammatory Bowel Diseases*
Intestinal Mucosa
Th17 Cells*

Substances

Cytokines

Grants and funding

This study was funded by the National Natural Science Foundation of China, Grant/Award Numbers: 82200614; the National Natural Science Foundation of China, Grant/Award Numbers: 82070571; and the key talent cultivation plan of the excellent talent pool of the Army Military Medical University, Grant/Award Number: No.