Targeting lncRNAs of colorectal cancers with natural products

Woo Jung Sung; Jaewoo Hong

doi:10.3389/fphar.2022.1050032

Targeting lncRNAs of colorectal cancers with natural products

Front Pharmacol. 2023 Jan 9:13:1050032. doi: 10.3389/fphar.2022.1050032. eCollection 2022.

Authors

Woo Jung Sung¹, Jaewoo Hong²

Affiliations

¹ Department of Pathology, Daegu Catholic University School of Medicine, Daegu, South Korea.
² Department of Physiology, Daegu Catholic University School of Medicine, Daegu, South Korea.

Abstract

Non-coding RNA (ncRNA) is one of the functional classes of RNA that has a regulatory role in various cellular processes, such as modulation of disease onset, progression, and prognosis. ncRNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been actively studied in recent years. The change in ncRNA levels is being actively studied in numerous human diseases, especially auto-immune disorders and cancers; however, targeting and regulating ncRNA with natural products to cure cancer has not been fully established. Recently many groups reported the relationship between ncRNA and natural products showing promising effects to serve as additional therapeutic approaches to cure cancers. This mini-review summarizes the aspects of lncRNAs related to cancer biology focusing on colorectal cancers that natural products can target.

Keywords: colorectal cancer; lncRNA; lysosome; natural products; ncRNA; solid tumor.

Publication types

Review

Grants and funding

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2021R1I1A3043909).