Triglyceride-glucose index and estimated 10-year risk of a first hard cardiovascular event

Hua Qu; Lin-Zi Long; Li Chen; Han-Tao Wu; Chang-Geng Fu; Shan-Shan Zhang

doi:10.3389/fcvm.2022.994329

Triglyceride-glucose index and estimated 10-year risk of a first hard cardiovascular event

Front Cardiovasc Med. 2023 Jan 9:9:994329. doi: 10.3389/fcvm.2022.994329. eCollection 2022.

Authors

Hua Qu^{1

2

3}, Lin-Zi Long¹, Li Chen^{1

2}, Han-Tao Wu⁴, Chang-Geng Fu^{1

2}, Shan-Shan Zhang^{1

2

5}

Affiliations

¹ Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
² National Clinical Research Center for Chinese Medicine Cardiology, Beijing, China.
³ NMPA Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Beijing, China.
⁴ Beijing Liaoweiyuan Institute of Traditional Chinese Medicine, Beijing, China.
⁵ Xibeiwang Town Community Health Service Center, Beijing, China.

Abstract

Background: Whether Triglyceride-glucose (TyG) index is associated with 10-year risk of a first hard atherosclerotic cardiovascular disease (ASCVD) event in the United States remains unclear.

Methods: In this cross-sectional study, the participants, ranged from 40 to 79 years old, were from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. TyG index was the independent variable and 10-year risk of a first hard ASCVD was the dependent variable. The other variables, such as age, gender, race, body mass index (BMI), hypertension treatment states, smoking states and low-density lipoprotein cholesterol (LDL-C) et al. were considered as the potential confounding factors. Multivariate linear regression models and smooth curve fittings were used to evaluate the association between TyG index and 10-year risk of a first hard ASCVD event.

Results: A total of 2,142 participants were included in the analysis. The results showed that TyG index was associated with an increased 10-year risk of a first hard ASCVD event [β = 2.208, 95% (1.716, 2.700), P < 0.00001]. The association had statistical significance in both men [β = 3.862 95% CI (3.274, 4.450), P < 0.00001] and women [β = 1.067, 95% CI (0.286, 1.849), P = 0.00756)] according to subgroup analysis. Smooth curve fittings revealed that TyG index was linearly associated with 10-year risk of ASCVD in both male and female.

Conclusion: Triglyceride-glucose index was associated with an increased 10-year risk of a first hard ASCVD event in the United States, suggesting it is necessary to monitor and control an appropriate range of TyG index.

Keywords: 10-year risk; NHANES; TyG index; atherosclerotic cardiovascular disease; cross-sectional study.

Grants and funding

This work was supported by Young scholar of China association for science and technology (No. 2020-QNRCI-02), Fundamental research funds for the central public Welfare Research Institutes (No. ZZ15-YQ-006), and the project of National Natural Science Foundation of China (Grant No. 82104678).