Metabolomics as a potential tool for monitoring patients with aneurysmal subarachnoid hemorrhage

Nebojsa Lasica; Vidak Raicevic; Nikola M Stojanovic; Djula Djilvesi; Igor Horvat; Bojan Jelaca; Filip Pajicic; Petar Vulekovic

doi:10.3389/fneur.2022.1101524

Metabolomics as a potential tool for monitoring patients with aneurysmal subarachnoid hemorrhage

Front Neurol. 2023 Jan 9:13:1101524. doi: 10.3389/fneur.2022.1101524. eCollection 2022.

Authors

Nebojsa Lasica^{1

2}, Vidak Raicevic³, Nikola M Stojanovic⁴, Djula Djilvesi^{1

2}, Igor Horvat², Bojan Jelaca^{1

2}, Filip Pajicic^{1

2}, Petar Vulekovic^{1

2}

Affiliations

¹ Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
² Clinic of Neurosurgery, University Clinical Center of Vojvodina, Novi Sad, Serbia.
³ Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
⁴ Department of Physiology, Faculty of Medicine, University of Niš, Niš, Serbia.

Abstract

Metabolomics has evolved into a particularly useful tool to study interactions between metabolites and serves as an aid in unraveling the complexity of entire metabolomes. Nonetheless, it is increasingly viewed as a methodology with practical applications in the clinical setting, where identifying and quantifying biomarkers of interest could prove useful for diagnostics. Starting from a concise overview of the most prominent analytical techniques employed in metabolomics, herein we present a review of its application in studies of brain metabolism and cerebrovascular diseases, paying most attention to its uses in researching aneurysmal subarachnoid hemorrhage. Both animal models and human studies are considered, and metabolites identified as potential biomarkers are highlighted.

Keywords: intracranial aneurysm; metabolomics; metabonomics; neurocritical care; stroke; subarachnoid hemorrhage.

Publication types

Review