The Association of Inflammatory Markers with Maternal-Neonatal Outcome After Cervical Cerclage

Jiaoning Fang; Yingying Lin; Zhiwei Chen; Yan Lin; Mian Pan

doi:10.2147/JIR.S393666

The Association of Inflammatory Markers with Maternal-Neonatal Outcome After Cervical Cerclage

J Inflamm Res. 2023 Jan 19:16:245-255. doi: 10.2147/JIR.S393666. eCollection 2023.

Authors

Jiaoning Fang^#¹, Yingying Lin^#², Zhiwei Chen^#³, Yan Lin¹, Mian Pan¹

Affiliations

¹ Department of Obstetrics, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People's Republic of China.
² Department of Healthcare, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People's Republic of China.
³ Department of Gynecologic, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People's Republic of China.

^# Contributed equally.

Abstract

Objective: Cervical cerclage is effective in prolonging the number of weeks gestation in patients with cervical insufficiency(CI). However, valuable predictors with successful cervical cerclage remain limited. It aimed to evaluate the value of the systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) to predict the outcomes of cervical cerclage.

Methods: This study analyzed 374 participants. Inflammatory markers were calculated using maternal peripheral blood. The association of inflammatory markers and the outcome of cervical cerclage were analyzed. And the optimal cut-off values of inflammatory markers were calculated. Also, the Chi-square test and logistic and linear regression analyses were performed to evaluate inflammatory markers with the maternal outcome and neonatal outcomes.

Results: 374 pregnancies were included in this study. Finally, 268 (71.7%) participants suffered successful cervical cerclage. This study demonstrated that the baseline BMI (cm²/kg), the bulging membrane, cervical dilation (≥2cm), the amniotic sac herniation, the neutrophils counts, the systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were significant difference between the successful and unsuccessful groups (all P<0.05). Additionally, maternal blood inflammatory markers, such as WBC, lymphocyte, neutrophils, monocyte, platelet counts, SII, and SIRI, were significantly associated with maternal-neonatal outcomes. Furthermore, the results demonstrated that the SII level had the highest OR (OR=4.626; 95% CI (2.500-8.560)), as well as the following: SIRI level (OR = 3.795; 95% CI (1.989-7.242)), cervical dilation (≥2cm) (OR =3.477; 95% CI (1.458-10.844)), and amniotic sac herniation (OR = 1.796; 95% (0.473-4.975)).

Conclusion: This study demonstrated that the baseline SII level and SIRI level are important biochemical markers for predicting the outcome of cervical cerclage and maternal-neonatal outcomes with non-invasive procedures. They can help to provide personalized treatment before surgery and enhance postoperative surveillance.

Keywords: cervical cerclage; inflammatory markers; maternal-neonatal; outcome; peripheral blood.

Grants and funding

This work was funded by grants from the Fujian Science and Technology Innovation Joint Fund Project (2020Y9148), Natural Science Foundation of Fujian Province (No.2021J01406) and Fujian Provincial Technology Innovation Project (grant no. 2020Y9147), Natural Science Foundation of Fujian Province (No.2021J01420).