Dietary quality indices and recurrent chronic kidney disease in Taiwanese post-renal transplant recipients

I-Hsin Lin; Te-Chih Wong; Tuyen Van Duong; Shih-Wei Nien; I-Hsin Tseng; Hsu-Han Wang; Yang-Jen Chiang; Shwu-Huey Yang

doi:10.3389/fnut.2022.1023000

Dietary quality indices and recurrent chronic kidney disease in Taiwanese post-renal transplant recipients

Front Nutr. 2023 Jan 9:9:1023000. doi: 10.3389/fnut.2022.1023000. eCollection 2022.

Authors

I-Hsin Lin^{1

2}, Te-Chih Wong³, Tuyen Van Duong², Shih-Wei Nien¹, I-Hsin Tseng¹, Hsu-Han Wang^{4

5}, Yang-Jen Chiang^{4

5}, Shwu-Huey Yang^{2

6

7}

Affiliations

¹ Department of Medical Nutrition Therapy, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
² School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
³ Department of Nutrition and Health Sciences, Chinese Culture University, Taipei, Taiwan.
⁴ Department of Urology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁵ School of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁶ Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
⁷ Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan.

Abstract

Background: This study investigated the association between dietary quality indices and recurrent chronic kidney disease (rCKD) in Taiwanese post-renal transplant recipients (RTRs).

Methods: This prospective study recruited RTRs aged >18 years with a functioning allograft and without any acute rejection in the past 3 months from September 2016 to June 2018. Dietary quality indices included the Alternative Healthy Eating Index (AHEI) and AHEI-2010, and the Taiwanese version of the AHEI (AHEI-Taiwan) was calculated using 3-day dietary records, and calculated scores were divided into quartiles. Laboratory data were collected from medical records. rCKD was defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m². Logistic regression analysis was performed to analyze the associations.

Results: This study included 102 RTRs. The RTRs with higher AHEI, AHEI-Taiwan, and AHEI-2010 scores were older and had higher eGFRs and lower odds of rCKD. As compared with the lowest quartile, patients with the highest quartiles of the AHEI [odds ratio (OR), 0.10; 95% confidence interval (95% CI): 0.02, 0.49; p-trend = 0.004), AHEI-2010 (OR, 0.17; 95% CI: 0.04, 0.72; p-trend = 0.016], and AHEI-Taiwan (OR, 0.13; 95% CI: 0.03-0.59; p-trend = 0.008) had lower odds of rCKD, respectively. As compared with the lowest quartile, patients who consumed the highest quartiles of red and processed meat had 11.43 times higher odds of rCKD (OR, 11.43; 95% CI: 2.30-56.85; p for trend <0.01).

Conclusion: Higher dietary quality indices are associated with lower odds of rCKD in Taiwanese RTRs. Particularly, a positive association between a higher intake of red meat and processed meat and higher odds of rCKD remained exists after transplantation in Taiwanese RTRs. Further dietary guidelines and individualized dietary education were necessary for RTRs to prevent graft function deterioration.

Keywords: Taiwan; chronic kidney disease; dietary quality; kidney function; renal transplant recipients.

Grants and funding

This research was funded by the Chang Gung Memorial Hospital, grant number CMRPG3F2001-2.